Evidence map›Paper›PMID 35654338›Full record

ReviewVeterinary journal (London, England : 1997)2022

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine.

Sara J Lawrence-Mills, David Hughes, Melanie J Hezzell, Matthew Butler, Chris Neal, Rebecca R Foster, Gavin I Welsh, Natalie Finch

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Veterinary journal (London, England : 1997), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Visualising the endothelial glycocalyx in dogs.Veterinary journal (London, England : 1997) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sara J Lawrence-MillsBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK; current affiliation The Royal Veterinary College, University of London, North Mimms, UK. Electronic address: slawrencemills21@rvc.ac.uk.
David HughesBristol Veterinary School, University of Bristol, Langford, UK.
Melanie J HezzellBristol Veterinary School, University of Bristol, Langford, UK.
Matthew ButlerBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Chris NealBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Rebecca R FosterBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Gavin I WelshBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Natalie FinchBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Veterinary School, University of Bristol, Langford, UK; Langford Vets, Langford House, Langford, UK.
University of Bristol · GBThe Langton Grammar School for Boys · GBUniversity of London · GB

Funding

Medical Research Council MR/M018237/1Medical Research Council MR/W024187/1
6 · The paper itself

Abstract

The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.

Indexed as

Endothelial CellsGlycocalyxAnimalsCatsDogsEndothelium, VascularHumansDetectionDiagnosisDiseasePhysiologyVisualisation

Identifiers

PMID35654338
PMCPMC9587354
OpenAlexW4281644568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.