ArticleNature genetics2022
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
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In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 5 pooled it
27.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 5 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Protective effects of salidroside on NAFLD rodent models by alleviating oxidative stress and inflammation: a meta-analysis and mechanism exploration.Frontiers in pharmacology · 2026Pooled it
- Meta-Analysis: Effects of Steatotic Liver Disease-Associated Genetic Risk Alleles on Longitudinal Outcomes.Alimentary pharmacology & therapeutics · 2025Pooled it
- Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men.Nature communications · 2025Pooled it
- Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.Nature genetics · 2023Pooled it
- Genetic association stratified by HLA-DR3 and HLA-DR4 status reveals heterogeneity in pathways of progression to type 1 diabetes.Diabetologia · 2026Article
- Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans.International journal of molecular sciences · 2026Article
- Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Prediagnostic Plasma Metabolite Profiles and Prediction of Hepatocellular Carcinoma Risk: The Multiethnic Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Genetics of MASLD: a diabetes perspective.Diabetologia · 2026Review
- Review
- Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease.Nature genetics · 2026Article
- Pharmacologic management of metabolic and alcohol-associated liver disease.Metabolism and target organ damage · 2026Article
- The versatile interplay between steatotic liver disease and liver cancer.Nature reviews. Cancer · 2026Review
- Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis.Nature reviews. Gastroenterology & hepatology · 2026Review
- Genetically Informed Single-Cell Analysis RevealsMetabolites · 2026Article
- Observational
- Prediction of trajectories and outcomes in early-stage metabolic dysfunction-associated steatotic liver disease: a narrative review.EClinicalMedicine · 2026Review
- Risk Assessment and Prediction of Hepatocellular Carcinoma in Noncirrhotic Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Review
- Editorial on "Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease".Clinical and molecular hepatology · 2026Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
94 authors at 20 institutions in 4 countries.
Marijana Vujkovic *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4924-5714
Shweta Ramdas *Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kim M LorenzCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8674-2942
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Rebecca DarlayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Heather J CordellPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-1879-5572
Jing HeDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yevgeniy GindinGilead Sciences, Inc., Foster City, CA, USA.
Chuhan ChungGilead Sciences, Inc., Foster City, CA, USA.
Robert P MyersGilead Sciences, Inc., Foster City, CA, USA.
Carolin V SchneiderDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Joseph ParkDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3313-641X
Kyung Min LeeVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8995-0448
Marina SerperCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Rotonya M CarrDivision of Gastroenterology, University of Washington, Seattle, WA, USA.
David E KaplanCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3839-336X
Mary E HaasBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew T MacLeanDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Walter R WitscheyDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1669-2120
Xiang ZhuVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-1134-6413
Catherine TcheandjieuVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-9559-4339
Rachel L KemberMental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8820-2659
Henry R KranzlerMental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Anurag VermaCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Ayush GiriDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7786-4670
Derek M KlarinVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-4636-5780
Yan V SunAtlanta VA Medical Center, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Jie HuangSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0002-9036-4304
Jennifer E HuffmanVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-2491
Kate Townsend CreasyDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1870-4586
Nicholas J HandDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8172-1816
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Michelle T LongDepartment of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, MA, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Matthew BudoffDepartment of Cardiology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-9616-1946
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiaohui LiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Henry J LinThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-6771-0486
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ruey-Kang ChangThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ronald M KraussDepartments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA.
Silvia VilarinhoSection of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2099-4212
Joseph BrancaleSection of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Jonas B NielsenRegeneron Genetics Center, Tarrytown, NY, USA.
Adam E LockeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6227-198X
Marcus B JonesRegeneron Genetics Center, Tarrytown, NY, USA.
Niek VerweijRegeneron Genetics Center, Tarrytown, NY, USA.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
K Rajender ReddyDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Brent A Neuschwander-TetriDepartment of Internal Medicine, Saint Louis University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8520-7398
Jeffrey B SchwimmerDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Arun J SanyalDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Naga ChalasaniDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathleen A RyanProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1158-8455
Braxton D MitchellProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7312-7078
Andrew D WellsDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Elisabetta ManduchiDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4110-3714
Yedidya SaimanDepartment of Medicine, Section of Hepatology, Lewis Katz School of Medicine at Temple University, Temple University Hospital, Philadelphia, PA, USA.
Nadim MahmudDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Donald R MillerCenter for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.ORCID http://orcid.org/0000-0002-7881-8801
Peter D ReavenPhoenix VA Health Care System, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-8923-6690
Lawrence S PhillipsAtlanta VA Medical Center, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-6542-8046
Sumitra MuralidharOffice of Research and Development, Veterans Health Administration, Washington, DC, USA.
Scott L DuVallVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-4898-3865
Jennifer S LeeVA Palo Alto Health Care System, Palo Alto, CA, USA.
Themistocles L AssimesVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Saiju PyarajanVA Boston Healthcare System, Boston, MA, USA.
Kelly ChoVA Boston Healthcare System, Boston, MA, USA.
Todd L EdwardsNashville VA Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Scott M DamrauerCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8009-1632
Peter W WilsonAtlanta VA Medical Center, Decatur, GA, USA.
J Michael GazianoVA Boston Healthcare System, Boston, MA, USA.
Christopher J O'DonnellVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2667-8624
Amit V KheraProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6535-5839
Struan F A GrantDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Christopher D BrownDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Philip S TsaoVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7274-9318
Danish SaleheenDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6193-020X
Luca A LottaRegeneron Genetics Center, Tarrytown, NY, USA.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Quentin M AnsteeFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Ann K DalyNewcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
James B MeigsProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Julie A LynchVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Regeneron Genetics Center
Geisinger-Regeneron DiscovEHR Collaboration
EPoS Consortium
VA Million Veteran Program
Daniel J Rader *Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Benjamin F Voight *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-6205-9994
Kyong-Mi Chang *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-6811-9364
University of Pennsylvania · USUCLA Medical Center · USPhiladelphia VA Medical Center · USRegeneron (United States) · USBrigham and Women's Hospital · USBroad Institute · USVA Palo Alto Health Care System · USEmory University · USGilead Sciences (United States) · USTranslational Therapeutics (United States) · USVanderbilt University Medical Center · USBoston University · USChildren's Hospital of Philadelphia · USNewcastle University · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBUniversity of Maryland, Baltimore · USUniversity of Massachusetts Lowell · USYale University · USColumbia University Irving Medical Center · USImperial College London · GB
Funding
Glycemia Reduction Approaches in Diabetes: A comparative effectiveness studyU01DK098246 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI KRAUSE-STEINRAUF, HEIDI, LACHIN, JOHN M · 2012 to 2022
$238.9MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MImplementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MTranslational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4MNon Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2MVEDS Year2-Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating CenterU24DK061730 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JEANNE M CLARK, David M Shade · 2019 to 2026
$11.3MHARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5MGenome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MNonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)U01DK061738 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Norah A. Terrault · 2002 to 2026
$8.9MFunctional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8MHigh Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6MBLRD VA I01 BX003341BLRD VA I01 BX003362BLRD VA I01 BX005831CSRD VA I01 CX001737CSRD VA IK2 CX001780NCATS NIH HHS UL1 TR001878NCATS NIH HHS UL1 TR002378NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL134853NHLBI NIH HHS R01 HL137984NHLBI NIH HHS R01 HL151855NHLBI NIH HHS T32 HL007734NIAAA NIH HHS R01 AA026302NIAID NIH HHS R01 AI123539NIAID NIH HHS R03 AI133172NIAID NIH HHS R21 AI156161NIBIB NIH HHS P41 EB029460NICHD NIH HHS R01 HD056465NIDDK NIH HHS K08 DK124577NIDDK NIH HHS K23 DK113252NIDDK NIH HHS K23 DK115897NIDDK NIH HHS P30 DK111024NIDDK NIH HHS R01 DK101478NIDDK NIH HHS R01 DK114291NIDDK NIH HHS R01 DK122586NIDDK NIH HHS R01 DK127083NIDDK NIH HHS R01 DK131033NIDDK NIH HHS R21 DK099716NIDDK NIH HHS R56 DK101478NIDDK NIH HHS U01 DK061732NIDDK NIH HHS U01 DK061738NIDDK NIH HHS U01 DK078616NIDDK NIH HHS U01 DK098246NIDDK NIH HHS U24 DK061730NIDDK NIH HHS UM1 DK078616NIDDK NIH HHS UM1 DK126194NLM NIH HHS R01 LM010685
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P < 5 × 10
Indexed as
Genome-Wide Association StudyNon-alcoholic Fatty Liver DiseaseAlanine TransaminaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOHumansIntracellular Signaling Peptides and ProteinsLipaseMembrane ProteinsPolymorphism, Single NucleotideProtein Serine-Threonine KinasesAlanine TransaminaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanIntracellular Signaling Peptides and ProteinsLipaseMembrane ProteinsProtein Serine-Threonine KinasesTRIB1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.