Evidence map›Paper›PMID 35655710›Full record

ReviewAlcohol research : current reviews2022

Alcohol-Endocannabinoid Interactions: Implications for Addiction-Related Behavioral Processes.

Antonia Serrano, Luis A Natividad

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alcohol research : current reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  14. Article
  15. Review
  16. Alcohol and Cannabinoids - From the Editors.Alcohol research : current reviews · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Antonia SerranoInstituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Luis A NatividadCollege of Pharmacy, Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, Texas, USA.
Hospital Regional Universitario de Málaga · ES

Funding

Identification of novel mechanisms in alcohol-induced cognitive dysfunctionR00AA025393 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI NATIVIDAD, LUIS ALBERTO · 2020 to 2022
$747k
Identification of novel mechanisms in alcohol-induced cognitive dysfunctionK99AA025393 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI NATIVIDAD, LUIS ALBERTO · 2017 to 2018
$284k
NIAAA NIH HHS K99 AA025393NIAAA NIH HHS R00 AA025393
6 · The paper itself

Abstract

purposeThe endogenous cannabinoid system is involved in several physiological functions in the central nervous system including the modulation of brain reward circuitry and emotional homeostasis. Substantial evidence implicates brain endocannabinoid signaling in the processing of drug-induced reward states, wherein repeated exposure besets pathological changes in activity that contribute to the progression of alcohol use disorder. This review provides a narrative summary of recent studies exploring the interaction between alcohol exposure and changes in endocannabinoid signaling that may underlie the development of alcohol use disorder. SEARCH

methodsThe authors began with an initial search for review articles to assist in the identification of relevant literature. This was followed by separate searches for primary literature and recent studies. The search terms "alcohol/ethanol" and "endocannabinoids" were applied, along with terms that covered specific objectives in reinforcement and addiction behavior. The content was further refined by excluding articles containing a broad focus on psychiatric disorders, polysubstance abuse, non-cannabinoid signaling lipids, and other criteria. SEARCH

resultsThe initial search yielded a total of 49 review articles on PubMed, 13 on ScienceDirect, and 17 on Wiley Online, from which the authors garnered information from a total of 16 reviews. In addition to independent searches, this review provides information from a collection of 212 publications, including reviews and original research articles. DISCUSSION AND

conclusionsThe review discusses the effects of alcohol consumption on brain endocannabinoid signaling, including alcohol-based perturbations in endocannabinoid-mediated synaptic transmission, the modulation of alcohol-related behaviors by manipulating signaling elements of the endocannabinoid system, and the influence of dysregulated endocannabinoid function in promoting withdrawal-induced anxiety-like behavior. Notable emphasis is placed on studies exploring the possible therapeutic relevance of bolstering brain endocannabinoid tone at different stages of alcohol use disorder.

Indexed as

AlcoholismBehavior, AddictiveEndocannabinoidsEthanolHumansRewardEndocannabinoidsEthanol2-arachidonoylglycerolalcoholanandamideanxietycannabinoidsdependenceeffects on the brainreinforcing

Identifiers

PMID35655710
PMCPMC9132373
OpenAlexW4285244245

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.