ArticleMicrobiome2022
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 101 citations in OpenAlex.
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- Environmental microbial communities and host selection shape larval microbiomes.bioRxiv : the preprint server for biology · 2026Article
- Immune priming reshapes the microbiota and modulates pathogen dynamics in the Manila clam (Frontiers in microbiology · 2026Article
- Effects of neem extract on Artemia franciscana: Insights from high-throughput transcriptomics and phenotypic analysis.PloS one · 2026Article
- Microbial communities experienced during early development shape the host immune system and epigenome.iScience · 2025Article
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- Hemolymph microbiota and immune effectors' expressions driven by geographical rearing acclimation of the aquacultured Penaeus stylirostris.Animal microbiome · 2025Article
- Microbiome engineering to enhance disease resistance in aquaculture: current strategies and future directions.Frontiers in microbiology · 2025Review
- Influence of Temperature and Saline Conditions on Bacteria Naturally Associated With the Cnidarian HostInternational journal of microbiology · 2025Article
- Hatchery type influences the gill microbiome of Atlantic farmed salmon (Salmo salar) after transfer to sea.Animal microbiome · 2024Article
- Microbial education plays a crucial role in harnessing the beneficial properties of microbiota for infectious disease protection in Crassostrea gigas.Scientific reports · 2024Article
- Parent-Specific Transgenerational Immune Priming Enhances Offspring Defense-Unless Heat Stress Negates It All.Ecology and evolution · 2024Article
- The core microbiome of cultured Pacific oyster spat is affected by age but not mortality.Microbiology spectrum · 2024Article
- Review
- Laboratory Replication of Ostreid Herpes Virus (OsHV-1) Using Pacific Oyster Tissue Explants.Viruses · 2024Article
- Priority effects alter microbiome composition and increase abundance of probiotic taxa in treefrog tadpoles.Applied and environmental microbiology · 2024Article
- Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- To live or let die? Epigenetic adaptations to climate change-a review.Environmental epigenetics · 2024Review
- A common garden experiment supports a genetic component underlying the increased resilience of common cockle (Evolutionary applications · 2023Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation - and, importantly, protection from infectious disease - is still an open question.
resultsHere, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.
conclusionsWe anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. tag the videobyte/videoabstract in this section Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.