ArticleScientific reports2022
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 2 citations in OpenAlex.
- Detection of maternal and fetal stress from the electrocardiogram with self-supervised representation learning.Scientific reports · 2021Trial
- Cortisol Stress Response is Associated with Iron Status in Pregnancy.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Prenatal experience of greater neighborhood disadvantage is associated with altered fetal volumetric brain growth in utero.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Placental iron transport under maternal stress: a missing link in foetal programming and mental health.EBioMedicine · 2026Article
- Environmental Stressors, Anemia, and Depressive Symptoms in Pregnancy: Unpacking the Combined Risks.International journal of environmental research and public health · 2025Article
- Heart Rate Variability Patterns Reflect Yoga Intervention in Chronically Stressed Pregnant Women: A Quasi-Randomized Controlled Trial.Bioengineering (Basel, Switzerland) · 2025Article
- Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns.Molecular psychiatry · 2025Article
- Article
- Combined Restraint Stress and Metal Exposure Paradigms in Rats: Unravelling Behavioural and Neurochemical Perturbations.Molecular neurobiology · 2025Article
- Effects of prenatal iron deficiency on neurological development and related disorders in offspring.Frontiers in nutrition · 2025Review
- Maternal-fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study.Clinical epigenetics · 2022Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adverse effects of maternal prenatal stress (PS) on child's neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
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