Evidence map›Paper›PMID 35664740›Full record

ArticleFrontiers in oncology2022

PET Imaging of Acidic Tumor Environment With

David Bauer, Hannah Visca, Anuradha Weerakkody, Lukas M Carter, Zachary Samuels, Spencer Kaminsky, Oleg A Andreev, Yana K Reshetnyak, Jason S Lewis

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Targeting the Vim-PGIHuman mutation · 2026
    Article
  4. Review
  5. Review
  6. Good practices forEJNMMI radiopharmacy and chemistry · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David BauerDepartment of Radiology and the Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Hannah ViscaDepartment of Physics, University of Rhode Island, Kingston, RI, United States.
Anuradha WeerakkodyDepartment of Physics, University of Rhode Island, Kingston, RI, United States.
Lukas M CarterDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Zachary SamuelsDepartment of Radiology and the Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Spencer KaminskyDepartment of Radiology and the Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Oleg A AndreevDepartment of Physics, University of Rhode Island, Kingston, RI, United States.
Yana K ReshetnyakDepartment of Physics, University of Rhode Island, Kingston, RI, United States.
Jason S LewisDepartment of Radiology and the Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
TM INTERACTIONS IN MEMBRANE PROTEIN FOLDING AND FUNCTIONR01GM073857 · NIGMS · YALE UNIVERSITY · PI ANDREEV, OLEG A, ENGELMAN, DONALD M. · 2006 to 2023
$8.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Development of a Novel Peptide Platform for Targeted PET Imaging and Radiotherapy of Breast CancerF32EB025050 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI CARTER, LUKAS MICHAEL · 2017 to 2019
$179k
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130NIBIB NIH HHS F32 EB025050NIGMS NIH HHS R01 GM073857
6 · The paper itself

Abstract

Acidosis of the tumor microenvironment is a hallmark of tumor progression and has emerged as an essential biomarker for cancer diagnosis, prognosis, and evaluation of treatment response. A tool for quantitatively visualizing the acidic tumor environment could significantly advance our understanding of the behavior of aggressive tumors, improving patient management and outcomes.

Indexed as

acidic tumor microenvironmenthuman dosimetry estimatesmembrane-insertion behaviorPET imagingpH-low insertion peptideszirconium-89

Identifiers

PMID35664740
PMCPMC9160799

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.