Evidence map›Paper›PMID 35665242›Full record

ArticleFrontiers in cardiovascular medicine2022

Elastin Insufficiency Confers Proximal and Distal Pulmonary Vasculopathy in Mice, Partially Remedied by the K

Russell H Knutsen, Leah M Gober, Elise K Kronquist, Maninder Kaur, Danielle R Donahue, Danielle Springer, Zu Xi Yu, Marcus Y Chen, Yi-Ping Fu, Feri Choobdar and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The evolutionary origins of dementia.Journal of Alzheimer's disease reports
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Russell H KnutsenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Leah M GoberNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Elise K KronquistNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Maninder KaurNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Danielle R DonahueMouse Imaging Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Danielle SpringerMurine Phenotyping Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Zu Xi YuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Marcus Y ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Yi-Ping FuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Feri ChoobdarNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
My-Le NguyenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Sharon OsgoodNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Joy L FreemanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Neelam RajaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Mark D LevinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Beth A KozelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
National Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
Murine Phenotyping CoreZIGHL006190 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SPRINGER, DANIELLE · 2014 to 2025
$15.2M
Williams syndrome: A Translational Approach to Mechanism and TreatmentZIAHL006210 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2016 to 2024
$10.4M
Cardiovascular Clinical Section StudiesZICHL006199 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2017 to 2025
$8.8M
Novel Techniques for Vascular Investigation ZIAHL006247 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2020 to 2022
$739k
Intramural NIH HHS ZIA HL006210Intramural NIH HHS ZIA HL006247
6 · The paper itself

Abstract

Background: Williams Beuren syndrome (WBS) is a recurrent microdeletion disorder that removes one copy of elastin ( Methods: Computed tomography (CT) angiogram ( Results: WBS participants with a history of main or branch pulmonary artery (PA) stenosis requiring intervention continued to exhibit increased right ventricular systolic pressure (RVSP, echocardiogram) relative to their peers without intervention ( Conclusions: Vascular deficiencies beyond arterial caliber persist in individuals with WBS who have undergone PA stenosis intervention. Evaluation of

Indexed as

elastinminoxidilpulmonarypulmonary arterysex as a biological variablevasculopathyWilliams syndrome

Identifiers

PMID35665242
PMCPMC9160528
OpenAlexW4280614150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.