Evidence map›Paper›PMID 35665826›Full record

Observational studySleep2022

Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity.

Aaron Baugh, Russell G Buhr, Pedro Quibrera, Igor Barjaktarevic, R Graham Barr, Russell Bowler, Meilan King Han, Joel D Kaufman, Abigail L Koch, Jerry Krishnan and 13 more

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Short-term sleep benefitsFrontiers in pharmacology · 2026
    Pooled it
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4 · The record

Corrections and comments

  • Commented on by
    2023
5 · Who and what money

Authors and funding

23 authors at 15 institutions in 1 country.

Aaron BaughDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9527-691X
Russell G BuhrDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6159-7435
Pedro QuibreraCollaborative Studies Coordination Center, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Igor BarjaktarevicDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
R Graham BarrDepartment of Medicine, Columbia University, New York, NY, USA.
Russell BowlerDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Meilan King HanDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Joel D KaufmanDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4174-9037
Abigail L KochDepartment of Medicine, Veterans Administration Miami Healthcare, Miami, FL, USA.
Jerry KrishnanDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Wassim LabakiDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Fernando J MartinezDepartment of Medicine, Cornell University, Ithaca, NY, USA.
Takudzwa MkorombindoDepartment of Medicine, University of Alabama, Birmingham, AL, USA.
Andrew NamenDepartment of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.
Victor OrtegaDepartment of Medicine, Mayo Clinic, Phoenix, AZ, USA.
Robert PaineDepartment of Medicine, University of Utah, Salt Lake City, UA, USA.
Stephen P PetersDepartment of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.
Helena SchotlandDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Krishna SundarDepartment of Medicine, University of Utah, Salt Lake City, UA, USA.
Michelle R ZeidlerDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Prescott G WoodruffDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Neeta ThakurDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
University of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Michigan · USAtrium Health Wake Forest Baptist · USUniversity of Utah · USColumbia University · USCornell University · USJohns Hopkins University · USMiami VA Healthcare System · USNational Jewish Health · USUniversity of Alabama at Birmingham · USUniversity of Illinois Chicago · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USWinnMed · US

Funding

SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
SPIROMICS - Air Pollution StudyR01ES023500 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N, KAUFMAN, JOEL DANIEL · 2014 to 2018
$3.2M
Defining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
The Clinical Utility of Race-Specific Pulmonary Function in COPDF32HL158160 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAUGH, AARON DORIAN · 2021 to 2021
$55k
NCATS NIH HHS KL2 TR001882NCATS NIH HHS KL2TR001882NHLBI NIH HHS F32 HL158160NHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS L30 HL134025NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIEHS NIH HHS R01 ES023500NIEHS NIH HHS R01ES023500NIH HHS HHSN268200900013C
6 · The paper itself

Abstract

STUDY

objectivesSleep is an important dimension in the care of chronic obstructive pulmonary disease (COPD), but its relevance to exacerbations is unclear. We wanted to assess whether sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) is associated with an increased risk of COPD exacerbations and does this differ by socio-environmental exposures.

methodsWe included 1647 current and former smokers with spirometrically confirmed COPD from the SPIROMICS cohort. We assessed incidence rate ratios for exacerbation using zero-inflated negative binomial regression adjusting for demographics, medical comorbidities, and multiple metrics of disease severity, including respiratory medications, airflow obstruction, and symptom burden. Our final model adjusted for socio-environmental exposures using the Area Deprivation Index, a composite measure of contemporary neighborhood quality, and Adversity-Opportunity Index, a composite measure of individual-level historic and current socioeconomic indicators. We used a pre-determined threshold of 20% missingness to undertake multiple imputation by chained equations. As sensitivity analyses, we repeated models in those with complete data and after controlling for prior exacerbations. As an exploratory analysis, we considered an interaction between socio-environmental condition and sleep quality.

resultsAfter adjustment for all co-variates, increasing PSQI scores (range 0-21) were associated with a 5% increased risk for exacerbation per point (p = .001) in the imputed dataset. Sensitivity analyses using complete cases and after controlling for prior exacerbation history were similar. Exploratory analysis suggested less effect among those who lived in poor-quality neighborhoods (p-for-interaction = .035).

conclusionsPoor sleep quality may contribute to future exacerbations among patients with COPD. This represents one target for improving disease control. CLINICAL

trial registrationSubpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). ClinicalTrials.gov Identifier# NCT01969344. Registry URL: https://clinicaltrials.gov/ct2/show/.

Indexed as

Pulmonary Disease, Chronic ObstructiveSleep Wake DisordersDisease ProgressionHumansLungSeverity of Illness IndexSleep QualityCOPDexacerbationshealth disparitiesPSQIsleep quality

Identifiers

PMID35665826
PMCPMC9366643
OpenAlexW4281912863

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.