Evidence map›Paper›PMID 35666713›Full record

ArticleAging2022

TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction.

Qi Zhang, Yanan Li, Jiaxu Yu, Chunping Yin, Junfei Guo, Juan Zhao, Qiujun Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qi ZhangDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Yanan LiDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Jiaxu YuDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Chunping YinDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Junfei GuoDepartment of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Juan ZhaoExperimental Teaching Center of Hebei Medical University, Shijiazhuang 050017, Hebei, China.
Qiujun WangDepartment of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China.
Hebei Medical University · CNThird Hospital of Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice. Herein, WT and TLR3 KO neonatal mice, each with 24, were randomly divided into control group, sevoflurane group, and TLR3

Indexed as

Cognitive DysfunctionMethyl EthersAnimalsAnimals, NewbornApoptosisBrainHippocampusMiceNecrosisSevofluraneToll-Like Receptor 3Methyl EthersSevofluraneTLR3 protein, mouseToll-Like Receptor 3cognitive dysfunctionprogrammed necrosissevofluraneTLR3

Identifiers

PMID35666713
PMCPMC9217712
OpenAlexW4281676704

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.