Evidence map›Paper›PMID 35667713›Full record

ArticleBMJ open2022

Hypertension and retinal microvascular dysfunction (HyperVasc): protocol of a randomised controlled exercise trial in patients with hypertension.

Lukas Streese, Joséphine Gander, Justin Carrard, Christoph Hauser, Timo Hinrichs, Arno Schmidt-Trucksäss, Konstantin Gugleta, Henner Hanssen

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04763005 (Hypertension and Retinal Microvascular Dysfunction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04763005 nacompletednot on this map

Hypertension and Retinal Microvascular Dysfunction: A Cross-sectional and Randomized Controlled Exercise Trial

TypeinterventionalSponsorUniversity of BaselRan2021 to 2022Enrolled85ConditionsHypertensionArmsHIIT exercise intervention, Physical activity recommendations
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lukas StreeseDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland lukas.streese@unibas.ch.ORCID 0000-0003-3920-8610
Joséphine GanderDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Justin CarrardDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.ORCID 0000-0002-2380-105X
Christoph HauserDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Timo HinrichsDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Arno Schmidt-TrucksässDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Konstantin GugletaDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Henner HanssenDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypertension is a global healthcare burden that affects the structure and function of the macrocirculation and microcirculation and induces disease-specific end-organ damage. Vascular biomarkers are essential to timely diagnose this end-organ damage to improve cardiovascular (CV) risk stratification and medical decision making. Exercise therapy is an effective means to improve vascular health and reduce overall CV risk. However, it is still not clear whether high-intensity interval training (HIIT) is recommendable for patients with hypertension to reduce blood pressure, increase cardiorespiratory fitness and ameliorate vascular health. METHODS AND ANALYSIS: The 'Hypertension and retinal microvascular dysfunction' trial will investigate macrovascular and microvascular impairments in hypertensive patients compared with healthy controls to investigate hypertension-induced end-organ damage by using gold-standard methods as well as newly developed unique retinal microvascular biomarkers. In addition, this trial will investigate the reversibility of retinal end-organ damage by assessing the effects of an 8-week supervised and walking based HIIT on blood pressure, cardiorespiratory fitness as well as macrovascular and microvascular health, compared with a control group following standard physical activity recommendations. Primary outcome will be the arteriolar-to-venular diameter ratio. Secondary outcomes will be arteriolar and venular diameters as well as the flicker-light-induced dilation. Further outcomes will be other retinal microvascular biomarkers, flow-mediated dilation of the brachial artery as well as blood pressure, cardiorespiratory fitness, microalbuminuria, hypertensive retinopathy and classical CV risk markers. Analysis of variance and analysis of covariance will be used to investigate group differences between healthy controls and hypertensive patients and training effects in hypertensive patients, respectively. ETHICS AND DISSEMINATION: The Ethics Committee of Northwestern and Central Switzerland approved this study (EKNZ-2021-00086). All participants will give informed consent. TRIAL REGISTRATION NUMBER: NCT04763005.

Indexed as

Cardiorespiratory FitnessHigh-Intensity Interval TrainingHypertensionBiomarkersExerciseHumansRandomized Controlled Trials as TopicBiomarkersclinical physiologyhypertensionsports medicine

Identifiers

PMID35667713
PMCPMC9171229
OpenAlexW4282932873

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.