ArticleCardiovascular diabetology2022
Triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 4 of them syntheses that pooled it.
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86 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies.Cardiovascular diabetology · 2025Pooled it
- Triglyceride-glucose index's link to cardiovascular outcomes post-percutaneous coronary intervention in China: a meta-analysis.ESC heart failure · 2024Pooled it
- Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.Cardiovascular diabetology · 2024Pooled it
- Triglyceride-glucose index and coronary artery disease: a systematic review and meta-analysis of risk, severity, and prognosis.Cardiovascular diabetology · 2023Pooled it
- Insulin Resistance and Blood Pressure Control on Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- The mediating role of the triglyceride-glucose index in the association between lifestyle risk score and hypertension.BMC cardiovascular disorders · 2026Article
- Influence of Plasma Atherogenic Index on Coronary Artery Disease Severity: Insights From a Large-Scale Cohort Study in China.Reviews in cardiovascular medicine · 2026Article
- Interpretable machine learning analysis of routine blood biomarkers and derived indicators for predicting coronary heart disease in patients with carotid stenosis.BMC cardiovascular disorders · 2026Article
- A novel risk prediction model incorporating triglyceride-glucose-body mass index for in-hospital mortality in hypertensive patients with HFmrEF.Lipids in health and disease · 2026Article
- Associations of metabolic indicators and inflammation-related indices with adverse cardiovascular events in US adults: NHANES 1999-2018.Lipids in health and disease · 2026Article
- Associations of the TyG index, remnant cholesterol levels, and the severity of coronary artery disease: findings from a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Development and validation of the C-reactive protein-triglyceride-glucose index for predicting short- and long-term mortality in critically ill patients with coronary artery disease: a multicenter cohort study.Frontiers in cardiovascular medicine · 2026Article
- Predictive value of thyroid autoantibodies for coronary heart disease severity in individuals with normal thyroid function based on machine learning and SHAP interpretation.Frontiers in immunology · 2026Article
- Article
- Association of the Triglyceride Glucose Index and Epicardial Adipose Tissue with Type 2 Diabetes Mellitus Complicated by Coronary Atherosclerotic Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Additive value of combining triglyceride-glucose index and estimated glucose disposal rate for incident stroke prediction across glycaemic-regulation subgroups: a prospective cohort of 5,789 Chinese adults.Cardiovascular diabetology · 2025Article
- The triglyceride-glucose index and acute kidney injury risk in critically ill patients with coronary artery disease.Renal failure · 2025Article
- The Relationship Between the C-reactive Protein-Triglyceride Glucose Index and the Risk of Coronary Heart Disease Alongside the Severity of Coronary Artery Stenosis in Older Adults With Different Levels of Glucose Metabolism: A Real-World Retrospective Clinical Study.Reviews in cardiovascular medicine · 2025Article
- Article
- Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction.Cardiovascular diabetology · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTriglyceride glucose (TyG) index is a new marker associated with atherosclerosis. This study aimed to assess the association between TyG index and the severity of coronary artery disease (CAD) in patients with coronary heart disease (CHD) and further explore the association between TyG index and CAD severity in different glucose metabolic states.
methodsThis multi-centre retrospective study included 731 patients with CHD between January 1, 2014 and September 30, 2020 in China. All patients were stratified into groups based on the tertiles of TyG index (T1: 5.48 ≤ TyG index ≤ 7.17; T2: 7.18 ≤ TyG index ≤ 7.76; T3: 7.77 ≤ TyG index ≤ 10.82). The number of diseased vessels [single-vessel and multi-vessel CAD (≥ 50% stenosis in ≥ 2 large vessels)] represented the severity of CAD, which was measured using coronary angiography (CAG). Glucose metabolic states were defined by the American Diabetes Association as normal glucose regulation (NGR), prediabetes mellitus (Pre-DM), and diabetes mellitus (DM).
resultsThe baseline analysis results showed significant differences in the clinical and biological characteristics of CHD patients according to TyG index tertiles (P < 0.05 to < 0.001). Logistic regression analysis showed that the TyG index was significantly related to the risk of multi-vessel CAD (odds ratio [OR]: 1.715; 95% confidence interval [CI] 1.339-2.197; P < 0.001). The OR for multi-vessel CAD in TyG index T3 compared to that of T1 was 2.280 (95% CI 1.530-3.398; P < 0.001). Receiver operating characteristic (ROC) curve was generated to evaluate the accuracy of the TyG index in detecting the CAD severity, and the area under the curve (AUC) of the ROC plots was 0.601 (95% CI 0.559-0.643). The association between TyG index and multi-vessel CAD was significant in patients with DM, achieving the highest OR among the different glucose metabolic states (OR: 1.717; 95% CI 1.161-2.539; P < 0.05).
conclusionTyG index was associated with CAD severity in patients with CHD, and an increased TyG index could identify patients with a high risk of multi-vessel CAD. There was an association between TyG index and CAD severity for the condition of DM.
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