Evidence map›Paper›PMID 35672585›Full record

ReviewCellular and molecular life sciences : CMLS2022

Biological aspects in controlling angiogenesis: current progress.

Mohsen Akbarian, Luiz E Bertassoni, Lobat Tayebi

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Role of ZEB1 in angiogenesis and therapeutic potential (Review).International journal of molecular medicine · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Expression Analysis ofIranian journal of medical sciences · 2026
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Mohsen AkbarianDepartment of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan.
Luiz E BertassoniDivision of Biomaterials and Biomechanics, Department of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, Portland, OR, USA.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI, 53233, USA. lobat.tayebi@marquette.edu.ORCID http://orcid.org/0000-0003-1947-5658
Marquette University · USNational Cheng Kung University · TWOregon Health & Science University · US

Funding

Microengineering vascularized and innervated bone-like scaffolds as an alternative to autologous bone graftsR01DE029553 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI BERTASSONI, LUIZ EDUARDO · 2021 to 2025
$3.0M
Microengineering the Dental Pulp Vascular Microenvironment_Diversity SupplementR01DE026170 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI BERTASSONI, LUIZ EDUARDO · 2016 to 2020
$2.5M
Supplement: Development of an Integrated 3D Human Osteo-Mucosal ModelR15DE027533 · NIDCR · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2018 to 2021
$816k
An organ-on-a-chip model system to study prostate cancer metastasis into vascularized boneR21CA263860 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BERTASSONI, LUIZ EDUARDO, MORAN, AMY E · 2022 to 2023
$392k
Vascularization of critical-sized craniomaxillofacial defectsR56DE029191 · NIDCR · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2021 to 2021
$363k
NCI NIH HHS R21 CA263860NIDCR NIH HHS R01 DE026170NIDCR NIH HHS R01 DE029553NIDCR NIH HHS R15 DE027533NIDCR NIH HHS R56 DE029191
6 · The paper itself

Abstract

All living beings continue their life by receiving energy and by excreting waste products. In animals, the arteries are the pathways of these transfers to the cells. Angiogenesis, the formation of the arteries by the development of pre-existed parental blood vessels, is a phenomenon that occurs naturally during puberty due to certain physiological processes such as menstruation, wound healing, or the adaptation of athletes' bodies during exercise. Nonetheless, the same life-giving process also occurs frequently in some patients and, conversely, occurs slowly in some physiological problems, such as cancer and diabetes, so inhibiting angiogenesis has been considered to be one of the important strategies to fight these diseases. Accordingly, in tissue engineering and regenerative medicine, the highly controlled process of angiogenesis is very important in tissue repairing. Excessive angiogenesis can promote tumor progression and lack of enough angiogensis can hinder tissue repair. Thereby, both excessive and deficient angiogenesis can be problematic, this review article introduces and describes the types of factors involved in controlling angiogenesis. Considering all of the existing strategies, we will try to lay out the latest knowledge that deals with stimulating/inhibiting the angiogenesis. At the end of the article, owing to the early-reviewed mechanical aspects that overshadow angiogenesis, the strategies of angiogenesis in tissue engineering will be discussed.

Indexed as

Neovascularization, PhysiologicTissue EngineeringAnimalsHumansNeovascularization, PathologicRegenerative MedicineWound HealingAngiogenesisAnti-angiogenicsPro-angiogenicsTissue engineeringVascularization

Identifiers

PMID35672585
PMCPMC10171722
OpenAlexW4281742530

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.