ReviewJournal of diabetes and metabolic disorders2022
Metabolomics prospect of obesity and metabolic syndrome; a systematic review.
Review in Journal of diabetes and metabolic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Dynapenic obesity and all-Cause mortality: A systematic review and Meta-analysis of prospective cohort studies.Aging clinical and experimental research · 2025Pooled it
- Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes.Cardiovascular diabetology · 2023Trial
- Article
- Branched-Chain and Aromatic Amino Acids Mark Early Metabolic Shifts in Adults with Varying Adiposity.International journal of molecular sciences · 2026Article
- Blood-based obesity biomarkers and their relevance for disease risk.Nature reviews. Endocrinology · 2026Review
- Fecal Dysosmobacter spp. concentration is linked to plasma lipidome in insulin-resistant individuals with overweight, obesity and metabolic syndrome.Lipids in health and disease · 2025Article
- Serum tyrosine increases all-cause mortality in an older population.Frontiers in endocrinology · 2025Article
- Urinary signatures are associated with calorie restriction-mediated weight loss in obese Diversity Outbred mice.PloS one · 2025Article
- Exploring the mediating effects of amino acids on BMI and gestational diabetes mellitus: a longitudinal population-based cohort study.Frontiers in endocrinology · 2025Article
- Urinary amino acid metabolomic profiling and its association with childhood obesity in prepubescent individuals.Frontiers in physiology · 2025Article
- Profiling of Metabolome in the Plasma Following a circH19 Knockdown Intervention in Diet-Induced Obese Mice.Metabolites · 2024Article
- Sarcosine, Trigonelline and Phenylalanine as Urinary Metabolites Related to Visceral Fat in Overweight and Obesity.Metabolites · 2024Article
- Exploring the metabolomics profile of frailty- a systematic review.Journal of diabetes and metabolic disorders · 2024Review
- COVID-19 and Comorbidities: What Has Been Unveiled by Metabolomics?Metabolites · 2024Review
- Insight into the Predictive Power of Surrogate Diagnostic Indices for Identifying Individuals with Metabolic Syndrome.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Epigenome-wide association study of systemic effects of obesity susceptibility in human twins.Epigenetics · 2023Article
- The link between obesity and insulin resistance among children: Effects of key metabolites.Journal of diabetes · 2023Article
- Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts.Cardiovascular diabetology · 2023Article
- A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case-Control Studies.Metabolites · 2023Article
- A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals.BMC endocrine disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Due to growing concerns about the obesity pandemic as a worldwide phenomenon, a global effort has been made for managing it and associated disorders. Accordingly, metabolomics as a promising field of "OMICS" is presented for investigating different molecular pathways in obesity and related disorders through the evaluation of specific metabolites in both animal and human subjects. Herein, the aim of the present study as the first systematic review is to evaluate all available studies about different mechanisms and their biomarkers discovery using metabolomics approaches. Method: The study was designed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a comprehensive search strategy we searched in databases including; Web of Science, PubMed, and Scopus using specific keywords. Based on predefined inclusion/exclusion criteria study selection has been conducted considering the type of studies, participant, and outcome measures. Quality assessment was done using CASP (Critical Appraisal Skills Programme) checklist followed by data extraction according to a predefined data extraction sheet. Results: Among the articles that resulted from electronic search, a total of 74 articles met our inclusion criteria. The most prevalent studied metabolites were amino acids and lipid derivatives and both targeted and non-targeted approaches were applied for metabolomics studies. Conclusion: This systematic review summarized a wide range of studies regardless of the age, history, language, and type of the study. Further studies are needed to compare the application of emerging methods in the treatment of obesity and related disorders. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-021-00917-w.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.