Evidence map›Paper›PMID 35675813›Full record

ArticleDevelopmental cell2022

IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells.

Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Xian ZhangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China; Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Songyuan LuoDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Minjie WangDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Qin HuangDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Wenqian FangDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Jie LiDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Tianxiao LiuDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Yuanyuan ZhangDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Diseases Research Institute, The First Affiliated Hospital, Hainan Medical University, Haikou 571199, China.
Zhiyong DengDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Cong-Lin LiuDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA; Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.
Shuling GuanDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Julio E AyalaDepartment of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Richard A FlavellDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Rohit N KulkarniDepartment of Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Junli GuoCardiovascular Diseases Research Institute, The First Affiliated Hospital, Hainan Medical University, Haikou 571199, China. Electronic address: guojl0511@126.com.
Zhangsuo LiuDepartment of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. Electronic address: zhangsuoliu@zzu.edu.cn.
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. Electronic address: gshi@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USFirst Affiliated Hospital of Zhengzhou University · CNHainan Medical University · CNHefei University of Technology · CNJoslin Diabetes Center · USVanderbilt University · USYale University · US

Funding

Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast cells in Alzheimer's DiseaseR01AG063839 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2020 to 2024
$3.1M
Role of group 2 innate lymphoid cells in myocardial infarctionR01HL157073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.7M
Role of ILC2 and eosinophils in abdominal aortic aneurysmR01HL151627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2021 to 2024
$2.7M
Inflammatory Mechanisms of AtherosclerosisR01HL034636 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LIBBY, PETER · 1985 to 2006
$1.9M
CONTROL OF GROWTH OF VASCULAR WALL CELLSR37HL034636 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 1993 to 2002
$1.2M
NHLBI NIH HHS R01 HL034636NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL151627NHLBI NIH HHS R01 HL157073NHLBI NIH HHS R37 HL034636NIA NIH HHS R01 AG063839
6 · The paper itself

Abstract

Diabetic patients show elevated plasma IL18 concentrations. IL18 has two receptors: the IL18 receptor (IL18r) and the Na-Cl co-transporter (NCC). Here, we report that IL18 is expressed on islet α cells, NCC on β cells, and IL18r on acinar cells in human and mouse pancreases. The deficiency of these receptors reduces islet size, β cell proliferation, and insulin secretion but increases β cell apoptosis and exocrine macrophage accumulation after diet-induced glucose intolerance or streptozotocin-induced hyperglycemia. Together with the glucagon-like peptide-1 (GLP1), IL18 uses the NCC and GLP1 receptors on β cells to trigger β cell development and insulin secretion. IL18 also uses the IL18r on acinar cells to block hyperglycemic pancreas macrophage expansion. The β cell-selective depletion of the NCC or acinar-cell-selective IL18r depletion reduces glucose tolerance and insulin sensitivity with impaired β cell proliferation, enhanced β cell apoptosis and macrophage expansion, and inflammation in mouse hyperglycemic pancreas. IL18 uses NCC, GLP1r, and IL18r to maintain islet β cell function and homeostasis.

Indexed as

Insulin-Secreting CellsInterleukin-18PancreasAnimalsGlucagon-Like Peptide 1HumansInsulinInsulin SecretionMiceGlucagon-Like Peptide 1IL18 protein, humanInsulinInterleukin-18acinar cellsendocrineexocrineGLP1GLP1 receptorIL18IL18 receptorNa-Cl co-transporterα cellsβ cells

Identifiers

PMID35675813
PMCPMC9233156
OpenAlexW4281685984

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.