Evidence map›Paper›PMID 35676012›Full record

SynthesisBMJ open2022

Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis.

Haoyong Yuan, Zhongshi Wu, Ting Lu, Tingting Wei, Yifan Zeng, Yalin Liu, Can Huang

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00389220 (A Randomized Comparison of a Biolimus-Eluting Stent With a Sirolimus-Eluting Stent for Percutaneous Coronary Intervention), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00389220 nacompletednot on this map

A Randomized Comparison of a Biolimus-Eluting Stent With a Sirolimus-Eluting Stent for Percutaneous Coronary Intervention

TypeinterventionalSponsorBiosensors Europe SARan2006 to 2012Enrolled1,707ConditionsCoronary Disease, Coronary StenosisArmsCoronary stent placement
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Haoyong YuanDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China.
Zhongshi WuDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China.
Ting LuDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China.
Tingting WeiDepartment of Paediatrics, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China.
Yifan ZengDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China.
Yalin LiuDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China.
Can HuangDepartment of Cardiovascular Surgery, The second xiangya hospital of Central South University, Changsha, Hunan, China huangcan413@csu.edu.cn.ORCID 0000-0002-8659-9178
Central South University · CNHunan Provincial Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the safety and effectiveness between biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents (DP-DES) in patients with acute coronary syndrome (ACS).

designMeta-analysis of randomised controlled trials (RCTs). PRIMARY AND SECONDARY OUTCOME MEASURES: Major adverse cardiovascular events (MACEs) were considered the primary endpoint. Efficacy endpoints included target vessel revascularisation (TVR) and target lesion revascularisation (TLR). Safety endpoints included all-cause death, cardiac death, target vessel myocardial infarction and stent thrombosis (ST).

methodsWe searched PubMed, Medline, Embase and the Cochrane Controlled Register of Trials for comparative studies of BP-DES and DP-DES in patients with ACS from January 2000 to July 2021. Statistical pooling was performed to estimate incidence using a random-effects model with generic inverse-variance weighting. Risk estimates were computed with 95% CIs.

resultsEight articles with seven RCTs that compared BP-DES and DP-DES in patients with ACS were identified and included in the qualitative and quantitative analyses. There was no difference in the baseline characteristics, except for the number of smoking patients (OR: 1.13, 95% CI 1.03 to 1.24; p=0.008, I

conclusionThis meta-analysis revealed that both stent types demonstrated excellent safety and efficacy profiles at 12 months. However, a slight increase in MACEs, TLR, TVR and ST incidence was observed in the DP-DES group over the 2-year follow-up period, suggesting that BP-DES may be more favourable when treating patients with ACS. TRIAL REGISTRATION NUMBER: NCT00389220.

Indexed as

Acute Coronary SyndromeDrug-Eluting StentsPolymersAbsorbable ImplantsHumansRandomized Controlled Trials as TopicTreatment OutcomePolymersCoronary heart diseaseCoronary interventionMyocardial infarction

Identifiers

PMID35676012
PMCPMC9185674
OpenAlexW4282927671

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.