Structural and functional insights into the DNA damage-inducible protein 1 (Ddi1) from protozoa.

Killivalavan Asaithambi, Iman Biswas, Kaza Suguna

Open access · goldAbstract read

In one paragraph

Article in Current research in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation inmBio · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Killivalavan AsaithambiMolecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.

Iman BiswasMolecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.

Kaza SugunaMolecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.

Indian Institute of Science Bangalore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ddi1 is a multidomain protein that belongs to the ubiquitin receptor family of proteins. The Ddi1 proteins contain a highly conserved retroviral protease (RVP)-like domain along with other domains. The severity of opportunistic infections, caused by parasitic protozoa in AIDS patients, was found to decline when HIV protease inhibitors were used in antiretroviral therapy. Parasite growth was shown to be suppressed by a few of the inhibitors targeting Ddi1 present in these parasites. In this study, the binding of HIV protease inhibitors to the RVP domain of Ddi1 from

Indexed as

Active siteBLI, biolayer interferometryCrystal structureDdi1Ddi1, DNA damage-inducible protein 1FlapHDD, helical domain of Ddi1InhibitorNMA, normal mode analysisRVPRVP, retroviral proteaseUBA, ubiquitin-associatedUBL, ubiquitin-like

Identifiers

PMID35677776

DOI10.1016/j.crstbi.2022.05.003

PMCPMC9168383

OpenAlexW4281885179

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.