Evidence map›Paper›PMID 35678745›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Mitochondrial adaptations to inactivity in diaphragm muscle fibers.

Alyssa D Brown, Matthew J Fogarty, Leah A Davis, Debanjali Dasgupta, Carlos B Mantilla, Gary C Sieck

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025
    Review
  3. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Size-dependent differences in mitochondrial volume density in phrenic motor neurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alyssa D BrownDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4422-3356
Matthew J FogartyDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-0128-7042
Leah A DavisDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Debanjali DasguptaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Carlos B MantillaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-3040-9424
Mayo Clinic · US

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
Interdisciplinary Training in Lung Physiology and Biomedical EngineeringT32HL105355 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2012 to 2021
$3.9M
Impact of Airway Inflammation on MitochondriaR01HL157984 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2021 to 2024
$2.7M
Role of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL126451NHLBI NIH HHS R01 HL146114NHLBI NIH HHS R01 HL157984NHLBI NIH HHS T32 HL105355NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

Type I and IIa diaphragm muscle (DIAm) fibers comprise slow and fast fatigue-resistant motor units that are recruited to accomplish breathing and thus have a high duty cycle. In contrast, type IIx/IIb fibers comprise more fatigable fast motor units that are infrequently recruited for airway protective and straining behaviors. We hypothesize that mitochondrial structure and function in type I and IIa DIAm fibers adapt in response to inactivity imposed by spinal cord hemisection at C

Indexed as

DiaphragmMuscle Fibers, SkeletalMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaUbiquitin-Protein LigasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaUbiquitin-Protein Ligasesdiaphragminactivitymitochondria

Identifiers

PMID35678745
PMCPMC9291409
OpenAlexW4282916866

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.