Evidence map›Paper›PMID 35680376›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2022

Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.

Jared Tur, Sachin L Badole, Ravikumar Manickam, Kalyan C Chapalamadugu, Wanling Xuan, Wayne Guida, Jaret J Crews, Kirpal S Bisht, Srinivas M Tipparaju

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  5. Review
  6. NADCell communication and signaling : CCS · 2024
    Review
  7. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
  8. NAD in pathological cardiac remodeling: Metabolic regulation and beyond.Biochimica et biophysica acta. Molecular basis of disease · 2024
    Review
  9. Review
  10. Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jared TurDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Sachin L BadoleDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Ravikumar ManickamDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Kalyan C ChapalamaduguDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Wanling XuanDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Wayne GuidaDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Jaret J CrewsDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Kirpal S BishtDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA.
Srinivas M TipparajuDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy (J.T., S.L.B., R.M., K.C.C., W.X., S.M.T.) and Department of Chemistry, College of Arts and Sciences (W.G., J.J.C., K.S.B.), University of South Florida, Tampa, Florida, USA stippara@usf.edu.
University of South Florida · US

Funding

NIDDK NIH HHS R01 DK119066
6 · The paper itself

Abstract

Diabetes is associated with increased cardiac injury and sudden death. Nicotinamide phosphoribosyltransferase (Nampt) is an essential enzyme for the NAD

Indexed as

Diabetes Mellitus, ExperimentalMyocardial InfarctionAnimalsBlood GlucoseCarbazolesCytokinesMaleMiceNADNicotinamide PhosphoribosyltransferaseProto-Oncogene Proteins c-aktSirtuin 1Blood GlucoseCarbazolesCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseP7C3 compoundProto-Oncogene Proteins c-aktSirtuin 1

Identifiers

PMID35680376
PMCPMC9372916
OpenAlexW4282932565

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.