Evidence map›Paper›PMID 35682847›Full record

ReviewInternational journal of molecular sciences2022

Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol.

Aleksandra Zielińska, Amanda Cano, Tatiana Andreani, Carlos Martins-Gomes, Amélia M Silva, Marlena Szalata, Ryszard Słomski, Eliana B Souto

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Application of nanomedicines in tumor immunotherapy.Journal of molecular cell biology · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Aleksandra ZielińskaInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.ORCID 0000-0003-2603-1377
Amanda CanoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain.ORCID 0000-0001-9567-4283
Tatiana AndreaniCIQ-UP-Chemistry Research Centre, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0002-3794-8159
Carlos Martins-GomesCentre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados, 5001-801 Vila Real, Portugal.ORCID 0000-0002-1564-3661
Amélia M SilvaCentre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados, 5001-801 Vila Real, Portugal.ORCID 0000-0002-7524-9914
Marlena SzalataDepartment of Biochemistry and Biotechnology, Poznań University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.ORCID 0000-0002-0153-4317
Ryszard SłomskiInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0002-9737-6017
University of Trás-os-Montes and Alto Douro · PTInstitute of Human Genetics · PLInstitut de Nanociència i Nanotecnologia de la Universitat de BarcelonaUniversidade do Porto · PTUniversity of Life Sciences in Poznań · PL

Funding

the Institute of Human Genetics, Polish Academy of Sciences; National Science Centre, MINIATURA 4 2020/04/X/ST5/00789
6 · The paper itself

Abstract

Lipid nanoparticles are currently used to deliver drugs to specific sites in the body, known as targeted therapy. Conjugates of lipids and drugs to produce drug-enriched phospholipid micelles have been proposed to increase the lipophilic character of drugs to overcome biological barriers. However, their applicability at the topical level is still minimal. Phospholipid micelles are amphiphilic colloidal systems of nanometric dimensions, composed of a lipophilic nucleus and a hydrophilic outer surface. They are currently used successfully as pharmaceutical vehicles for poorly water-soluble drugs. These micelles have high in vitro and in vivo stability and high biocompatibility. This review discusses the use of lipid-drug conjugates as biocompatible carriers for cutaneous application. This work provides a metadata analysis of publications concerning the conjugation of cannabidiol with lipids as a suitable approach and as a new delivery system for this drug.

Indexed as

CannabidiolNanoparticlesDrug CarriersDrug Delivery SystemsLiposomesMicellesPhospholipidsCannabidiolDrug CarriersLipid NanoparticlesLiposomesMicellesPhospholipidscannabidiolcutaneous drug deliverylipid-drug conjugateslipid nanoparticlesmicelles

Identifiers

PMID35682847
PMCPMC9180973
OpenAlexW4282016639

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.