ArticleJournal of clinical medicine2022
Elevated Intrarenal Resistive Index Predicted Faster Renal Function Decline and Long-Term Mortality in Non-Proteinuric Chronic Kidney Disease.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Integrating kidney imaging for risk prediction, therapeutic monitoring, and prognostication across the kidney disease spectrum: a review of emerging evidence.Clinical kidney journal · 2026Review
- Duplex Doppler Measurement of Renal Resistive Index in Non-Dialysis Chronic Kidney Disease Outpatients: A Proposed Standardized Protocol.Diagnostics (Basel, Switzerland) · 2026Article
- Oxidative Stress and Endothelial Dysfunction in Patients with Hypertensive Nephropathy: Role of the Mediterranean Diet.International journal of molecular sciences · 2026Article
- Isolated Non-Albumin Proteinuria Was Associated with the Progression of Chronic Kidney Disease in Hypertensive Patients: A Retrospective Cohort Study.Kidney & blood pressure research · 2026Article
- Is it Always Safe to Administer RAS Inhibitors to Patients Who Underwent Unilateral Radical Nephrectomy?Case reports in nephrology · 2026Article
- Beyond biochemistry: multiparametric ultrasound parameters and their molecular correlates in cardio-renal-metabolic syndrome.Acta biochimica Polonica · 2026Review
- Effect of Combined Proteinuria and Increased Renal Resistive Index on Chronic Kidney Disease Progression: A Retrospective Longitudinal Study.Journal of clinical medicine · 2025Article
- The Effect of Risk Factors and Clinical Complications of Chronic Kidney Disease (CKD) on Renal Arterial Resistive Index (RRI).Current hypertension reviews · 2025Article
- Has the time come to change the treatment criteria for patients with chronic kidney disease? The "hypofiltering nephron" hypothesis.Frontiers in nephrology · 2025Article
- Analysis of risk factors for changes of renal artery resistance indexes in gout patients by ultrasound colour Doppler.Rheumatology advances in practice · 2024Article
- Association of renal resistive indices with kidney disease progression and mortality.BMC nephrology · 2023Article
- Mechanisms of Diabetic Nephropathy Not Mediated by Hyperglycemia.Journal of clinical medicine · 2023Review
- A nomogram for predicting the risk of intra-abdominal hypertension in critically ill patients based on ultrasound and clinical data.Quantitative imaging in medicine and surgery · 2023Article
- Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease.Diagnostics (Basel, Switzerland) · 2023Review
- Ultrasound Doppler Flow Parameters Are Independently Associated with Renal Cortex Contrast-Enhanced Multidetector Computed Tomography Perfusion and Kidney Function.Journal of clinical medicine · 2023Article
- New Landmarks to Slow the Progression of Chronic Kidney Disease.Journal of clinical medicine · 2022Article
- Favorable effect of renal denervation on elevated renal vascular resistance in patients with resistant hypertension and type 2 diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Intrarenal resistive index (RI) ≥ 0.80 predicts renal outcomes in proteinuric chronic kidney disease (CKD). However, this evidence in non-proteinuric patients with CKD of unknown etiology is lacking. In this study, we assessed the effect of intrarenal RI on renal function and all-cause mortality in non-proteinuric patients with CKD of unknown etiology despite an extensive diagnostic work-up. Methods. Non-proteinuric CKD patients were evaluated in a retrospective longitudinal study. Progression of renal disease was investigated by checking serum creatinine levels at 1, 3, and 5 years and defined by a creatinine level increase of at least 0.5 mg/dL. The discrimination performance of intrarenal RI in predicting the 5-year progression of renal disease was assessed by calculating the area under the receiver operating characteristic curve (AUROC). Results. One-hundred-thirty-one patients (76 ± 9 years, 56% males) were included. The median follow-up was 7.5 years (interquartile range 4.3−10.5) with a cumulative mortality of 53%, and 5-year renal disease progression occurred in 25%. Patients with intrarenal RI ≥ 0.80 had a faster increase of serum creatinine levels compared to those with RI < 0.80 (+0.06 mg/dL each year, 95% CI 0.02−0.10, p < 0.010). Each 0.1-unit increment of intrarenal RI was an independent determinant of 5-year renal disease progression (odds ratio 4.13, 95% CI 1.45−12.9, p = 0.010) and predictor of mortality (hazards ratio 1.80, 95% CI 1.05−3.09, p = 0.034). AUROCs of intrarenal RI for predicting 5-year renal disease progression and mortality were 0.66 (95% CI 0.57−0.76) and 0.67 (95% CI 0.58−0.74), respectively. Conclusions. In non-proteinuric patients with CKD of unknown etiology, increased intrarenal RI predicted both a faster decline in renal function and higher long-term mortality, but as a single marker, it showed poor discrimination performance.
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