Evidence map›Paper›PMID 35692632›Full record

ArticleiScience2022

A conditional counterselectable

Weimin Zhang, Ran Brosh, Laura H McCulloch, Yinan Zhu, Hannah Ashe, Gwen Ellis, Brendan R Camellato, Sang Yong Kim, Matthew T Maurano, Jef D Boeke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Promise of gene therapy for congenital neurologic disease due to GPI deficiency.Molecular therapy. Methods & clinical development · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Weimin ZhangInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Laura H McCullochInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Yinan ZhuInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Hannah AsheInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Gwen EllisInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Brendan R CamellatoInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Sang Yong KimDepartment of Pathology, NYU Langone Health, New York, NY 10016, USA.
Matthew T MauranoInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Institute for Systems Biology · USNYU Langone Health · US

Funding

Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
NHGRI NIH HHS RM1 HG009491
6 · The paper itself

Abstract

Overwriting counterselectable markers is an efficient strategy for removing wild-type DNA or replacing it with payload DNA of interest. Currently, one bottleneck of efficient genome engineering in mammals is the shortage of counterselectable (negative selection) markers that work robustly without affecting organismal developmental potential. Here, we report a conditional

Indexed as

BioengineeringBiotechnologyGenetic engineeringSynthetic biology

Identifiers

PMID35692632
PMCPMC9184564
OpenAlexW4281287599

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.