Evidence map›Paper›PMID 35693208›Full record

ArticleSTAR protocols2022

Measuring trogocytosis between ovarian tumor and natural killer cells.

Antonio Delgado-Gonzalez, Ying-Wen Huang, Ermelinda Porpiglia, Kenyi Donoso, Veronica D Gonzalez, Wendy J Fantl

Abstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonio Delgado-GonzalezDeparment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ying-Wen HuangDeparment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ermelinda PorpigliaBaxter Laboratory for Stem Cell Biology, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kenyi DonosoDeparment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Veronica D GonzalezBaxter Laboratory for Stem Cell Biology, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wendy J FantlDeparment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Role of the microenvironment in ovarian cancer metastasisR01CA234553 · NCI · WASHINGTON UNIVERSITY · PI FUH, KATHERINE CYNTHIA · 2019 to 2023
$2.1M
(PQ8) Biomarker identification by mass cytometry in peripheral blood of patients with renal cell carcinoma undergoing immune checkpoint therapyR21CA231280 · NCI · STANFORD UNIVERSITY · PI FANTL, WENDY JANE, LEPPERT, JOHN THOMAS · 2019 to 2020
$377k
NCI NIH HHS R01 CA234553NCI NIH HHS R21 CA231280NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Trogocytosis is an active transport mechanism by which one cell extracts a plasma membrane fragment with embedded molecules from an adjacent cell in a contact-dependent process leading to the acquisition of a new function. Our protocol, which has general applicability, consolidates and optimizes existing protocols while highlighting key experimental variables to demonstrate that natural killer (NK) cells acquire the tetraspanin CD9 by trogocytosis from ovarian tumor cells. For complete details on the use and execution of this protocol, please refer to Gonzalez et al. (2021).

Indexed as

Ovarian NeoplasmsTrogocytosisCell MembraneFemaleHumansKiller Cells, NaturalCancerCell BiologyCell cultureCell isolationFlow Cytometry/Mass CytometryImmunologyMicroscopyMolecular Biology

Identifiers

PMID35693208
PMCPMC9185020

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.