Evidence map›Paper›PMID 35694563›Full record

ArticleKidney international reports2022

Vasopressin for Post-kidney Transplant Hypotension.

Muhammad Y Jan, Sharon M Moe, Oluwafisayo Adebiyi, Jeannie Chen, John Powelson, Heather N Burney, Muhammad S Yaqub, Dennis P Mishler, Ranjani N Moorthi, Tim E Taber and 6 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Muhammad Y JanDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sharon M MoeDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Oluwafisayo AdebiyiDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jeannie ChenDepartment of Pharmacy, Indiana University Health, Indianapolis, Indiana, USA.
John PowelsonDivision Transplant Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Heather N BurneyDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Muhammad S YaqubDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Dennis P MishlerDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ranjani N MoorthiDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tim E TaberDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Melissa D AndersonDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yang LiDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Xiaochun LiDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jonathan A FridellDivision Transplant Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
William C GogginsDivision Transplant Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Asif A SharfuddinDivision of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University School of MedicineIndiana Clinical and Translational Sciences Institute · USIndiana University Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypotension after deceased donor kidney transplant (DDKT) is a risk factor for delayed graft function (DGF) and poor graft survival (GS). We hypothesize that vasopressin use in hypotensive DDKT recipients (DDKTRs) to increase blood pressure (BP) reduces DGF rates and is safe without increasing mortality. Methods: Group with vasopressin "study group" ( Results: Vasopressin group had lower mean maximum and minimum SBP and DBP in the operating room (OR). Median vasopressin start time post-DDKT was 2 hours (interquartile range [IQR] 1-6), and duration of use was 42 hours (IQR 24-63). DGF, creatinine at 1 year, and allograft biopsy rates were comparable. No deaths occurred during transplant hospitalization. Multivariable analysis did not find an effect of vasopressin use on GS. Conclusion: Treatment of hypotensive DDKTRs with vasopressin is safe and facilitated similar graft function and survival with that of nonhypotensive patients. In the absence of a randomized control trial, our study supports the safety of vasopressin therapy to prevent the adverse effects of hypotension.

Indexed as

deceased donor kidney transplantdelayed graft functiongraft survivalvasopressin

Identifiers

PMID35694563
PMCPMC9174042
OpenAlexW4226179753

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.