ReviewNeuron2022
Medial and orbital frontal cortex in decision-making and flexible behavior.
Review in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed.
- Article
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates.Nature human behaviour · 2026Article
- Distinct brain susceptibility alteration pattern in Parkinson's disease with drooling: evidence from quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.Nature neuroscience · 2026Article
- Anterior cingulate cortex monitors action state and action content in complex associative learning.eLife · 2026Article
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies.Neuron · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Aberrant fronto-limbic network in adolescents with attention-deficit/hyperactivity disorder: a multimodal MRI study using parallel ICA.European archives of psychiatry and clinical neuroscience · 2026Article
- Neural Reward Processing in Digital Addiction: A Dynamical Systems Theory of Reward Instability.Brain sciences · 2026Article
- Early effects of a novel 5-HTThe British journal of psychiatry : the journal of mental science · 2026Article
- Thyroid-stimulating hormone receptor mediates peripheral-central neuroimmune crosstalk in autoimmune thyroid diseases.BMC medicine · 2026Article
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Network-nodal tACS induces right-lateralization of thalamocortical connectivity.Scientific reports · 2026Article
- Association of MoCA-measured cognitive functions with decision-making capacity in older adults with cognitive impairment.BMC geriatrics · 2026Article
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.bioRxiv : the preprint server for biology · 2026Article
- Soccer heading and white matter microstructural changes: a two-year longitudinal cohort study.Brain imaging and behavior · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of investigations of decision-making, behavioral flexibility, and social behavior. We review studies conducted in humans, macaques, and rodents and argue that several regions with different functional roles can be identified in the dorsal anterior cingulate cortex, perigenual anterior cingulate cortex, anterior medial frontal cortex, ventromedial prefrontal cortex, and medial and lateral parts of the orbitofrontal cortex. There is increasing evidence that the manner in which these areas represent the value of the environment and specific choices is different from subcortical brain regions and more complex than previously thought. Although activity in some regions reflects distributions of reward and opportunities across the environment, in other cases, activity reflects the structural relationships between features of the environment that animals can use to infer what decision to take even if they have not encountered identical opportunities in the past.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.