Evidence map›Paper›PMID 35707971›Full record

ArticleJournal of Korean Neurosurgical Society2022

Optimal Duration of Dual Antiplatelet Therapy after Stent- Assisted Coil Embolization of Unruptured Intracranial Aneurysms : A Prospective Randomized Multicenter Trial.

Seung Pil Ban, O-Ki Kwon, Young Deok Kim, Bum-Tae Kim, Jae Sang Oh, Kang Min Kim, Chang Hyeun Kim, Chang-Hyun Kim, Jai Ho Choi, Young Woo Kim and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean Neurosurgical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

Seung Pil BanDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
O-Ki KwonDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Young Deok KimDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Bum-Tae KimDepartment of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Jae Sang OhDepartment of Neurosurgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Kang Min KimDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Chang Hyeun KimDepartment of Neurosurgery, Pusan National University Yangsan Hospital, Yangsan, Korea.
Chang-Hyun KimDepartment of Neurosurgery, Keimyung University Dongsan Medical Center, Daegu, Korea.
Jai Ho ChoiDepartment of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Young Woo KimDepartment of Neurosurgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
Yong Cheol LimDepartment of Neurosurgery, Ajou University Medical Center, Ajou University School of Medicine, Suwon, Korea.
Hyoung Soo ByounDepartment of Neurosurgery, Chungnam National University Sejong Hospital, Sejong, Korea.
Sukh Que ParkDepartment of Neurosurgery, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Joonho ChungDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Keun Young ParkDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Jung Cheol ParkDepartment of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hyon-Jo KwonDepartment of Neurosurgery, Chungnam National University Hospital, Daejeon, Korea.
Seoul National University · KRKeimyung University Dongsan Medical Center · KRSoonchunhyang University · KRYonsei University · KRAjou University · KRChungnam National University · KRChungnam National University Hospital · KRSoonchunhyang University Hospital Seoul · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KRUlsan College · KR

Funding

Korea Health Industry Development InstituteMinistry of Health and Welfare HC20C0057
6 · The paper itself

Abstract

objectiveStent-assisted coil embolization (SAC) has been increasingly used to treat various types of intracranial aneurysms. Delayed thromboembolic complications are major concerns regarding this procedure, so dual antiplatelet therapy with aspirin and clopidogrel is needed. However, clinicians vary the duration of dual antiplatelet therapy after SAC, and no randomized study has been performed. This study aims to compare the safety and efficacy of long-term (12 months) dual antiplatelet therapy and shortterm dual antiplatelet therapy (6 months) after SAC for patients with unruptured intracranial aneurysms (UIAs).

methodsThis is a prospective, randomized and multicenter trial to investigate the optimal duration of dual antiplatelet therapy after SAC in patients with UIAs. Subjects will receive dual antiplatelet therapy for 6 months (short-term group) or 12 months (longterm group) after SAC. The primary endpoint is the assessment of thromboembolic complications between 1 and 18 months after SAC. We will enroll 528 subjects (264 subjects in each group) and perform 1 : 1 randomization. This study will involve 14 topperforming, high-volume Korean institutions specializing in coil embolization.

resultsThe trial will begin enrollment in 2022, and clinical data will be available after enrollment and follow-up.

conclusionThis article describes that the aim of this prospective randomized multicenter trial is to compare the effect of short-term (6 months) and long-term (12 months) dual antiplatelet therapy on UIAs in patients undergoing SAC, and to find the optimal duration.

Indexed as

Dual anti-platelet therapyEndovascular proceduresIntracranial aneurysmStentsThromboembolism

Identifiers

PMID35707971
PMCPMC9666239
OpenAlexW4282983948

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.