Evidence map›Paper›PMID 35713402›Full record

ArticleeLife2022

Cre/

Fang Liu, Sekhar Kambakam, Maira P Almeida, Zhitao Ming, Jordan M Welker, Wesley A Wierson, Laura E Schultz-Rogers, Stephen C Ekker, Karl J Clark, Jeffrey J Essner and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  5. Advancing Knock-In Approaches for Robust Genome Editing in Zebrafish.bioRxiv : the preprint server for biology · 2025
    Article
  6. Early death and neuronal abnormalities inbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Lineage labeling with zebrafishbioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fang Liu *Department of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Sekhar Kambakam *Department of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.ORCID 0000-0002-3331-3754
Maira P Almeida *Department of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Zhitao Ming *Department of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Jordan M WelkerDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Wesley A WiersonDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Laura E Schultz-RogersDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Stephen C EkkerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States.ORCID 0000-0003-0726-4212
Karl J ClarkDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States.ORCID 0000-0002-9637-0967
Jeffrey J EssnerDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.ORCID 0000-0001-8816-3848
Maura McGrailDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.ORCID 0000-0001-9308-6189
Iowa State University · USWinnMed · US

Funding

In vivo model of microglia inflammasome signaling in neuroinflammationR24OD020166 · OD · IOWA STATE UNIVERSITY · PI CLARK, KARL J, EKKER, STEPHEN CARL · 2016 to 2023
$7.1M
Conditional genetics and precision genome editing resources for ZebrafishR24OD036201 · OD · IOWA STATE UNIVERSITY · PI KARL J CLARK, Stephen Carl Ekker · 2024 to 2026
$3.0M
NIH HHS R24 OD020166NIH HHS R24 OD036201
6 · The paper itself

Abstract

The ability to regulate gene activity spatially and temporally is essential to investigate cell-type-specific gene function during development and in postembryonic processes and disease models. The Cre/

Indexed as

CRISPR-Cas SystemsZebrafishAllelesAnimalsIntegrasesCre recombinaseIntegrasesconditional rescue and inactivationCre/loxCRISPR-Cas9developmental biologygeneticsGeneWeldgenomicsprecision targeted integrationzebrafish

Identifiers

PMID35713402
PMCPMC9270027
OpenAlexW4283073411

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.