Evidence map›Paper›PMID 35713404›Full record

ArticleeLife2022

Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia.

Carrie E Leonard, Jolie Quiros, Frances Lefcort, Lisa A Taneyhill

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carrie E LeonardDepartment of Avian and Animal Sciences, University of Maryland, College Park, College Park, United States.ORCID 0000-0002-2199-8637
Jolie QuirosDepartment of Avian and Animal Sciences, University of Maryland, College Park, College Park, United States.
Frances LefcortDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, United States.ORCID 0000-0002-2064-8678
Lisa A TaneyhillDepartment of Avian and Animal Sciences, University of Maryland, College Park, College Park, United States.ORCID 0000-0002-8630-2514
University of Maryland, College Park · USMontana State University · US

Funding

Neural crest and placode cell interactions during cranial gangliogenesisR01DE024217 · NIDCR · UNIV OF MARYLAND, COLLEGE PARK · PI TANEYHILL, LISA A · 2014 to 2018
$1.9M
Understanding trigeminal ganglion development through the lens of Familial DysautonomiaR03HD108480 · NICHD · UNIV OF MARYLAND, COLLEGE PARK · PI TANEYHILL, LISA A · 2022 to 2023
$155k
NICHD NIH HHS R03 HD108480NIDCR NIH HHS R01 DE024217
6 · The paper itself

Abstract

Familial dysautonomia (FD) is a sensory and autonomic neuropathy caused by mutations in elongator complex protein 1 (

Indexed as

Dysautonomia, FamilialAnimalsFacial PainMiceNeural CrestNeuronsReceptor Protein-Tyrosine KinasesTrigeminal GanglionReceptor Protein-Tyrosine Kinasesdevelopmental biologyfamilial dysautonomiamouseneural crest cellsplacode cellstrigeminal gangliontrigeminal nervestrks

Identifiers

PMID35713404
PMCPMC9273214
OpenAlexW4283032819

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.