Evidence map›Paper›PMID 35717599›Full record

ArticleAging cell2022

Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes.

Ruei-Lung Lin, Hilaree N Frazier, Katie L Anderson, Sami L Case, Adam O Ghoweri, Olivier Thibault

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The Impact of Overexpression of the Mouse Ortholog ofBiological psychiatry global open science · 2025
    Article
  5. Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ruei-Lung LinDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Hilaree N FrazierDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Katie L AndersonDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Sami L CaseDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-1004-7246
Adam O GhoweriDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.
Olivier ThibaultDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-3548-3466
University of Kentucky · US

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Metabolic syndrome and hippocampal Ca2+ dysregulation in aging-related memory decR01AG033649 · NIA · UNIVERSITY OF KENTUCKY · PI THIBAULT, OLIVIER · 2009 to 2019
$3.4M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG057461 · NIA · UNIVERSITY OF KENTUCKY · PI MURPHY, MICHAEL PAUL, VAN ELDIK, LINDA J · 2017 to 2021
$2.1M
NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG033649NIA NIH HHS T32 AG057461
6 · The paper itself

Abstract

Neuronal hippocampal Ca

Indexed as

Insulin3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAgingAnimalsCalciumCalcium Channel AgonistsGaitHippocampusMaleMotivationNeuronsPatch-Clamp TechniquesRatsRats, Inbred F344Somatosensory Cortex3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterCalciumCalcium Channel AgonistsInsulinambulationfallsGCaMP6imagingtherapytwo-photon

Identifiers

PMID35717599
PMCPMC9282843
OpenAlexW4283164761

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.