Evidence map›Paper›PMID 35719024›Full record

Trial reportEarly intervention in psychiatry2023

Family communication and the efficacy of family focused therapy in individuals at clinical high risk for psychosis with comorbid anxiety.

Arianna C O'Brien Cannon, Nicole E Caporino, Mary P O'Brien, David J Miklowitz, Jean M Addington, Tyrone D Cannon

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Early intervention in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Arianna C O'Brien CannonDepartment of Psychology, American University, Washington, District of Columbia, USA.ORCID 0000-0003-0765-9775
Nicole E CaporinoDepartment of Psychology, American University, Washington, District of Columbia, USA.
Mary P O'BrienDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
David J MiklowitzDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Behavior, University of California, California, Los Angeles, USA.ORCID 0000-0002-9647-6147
Jean M AddingtonDepartment of Psychiatry, University of Calgary, Calgary, Canada.ORCID 0000-0002-8298-0756
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
American University · USYale University · USNeurobehavioral Systems · USUniversity of Calgary · CA

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
Prevention Trial of Family Focused Treatment in Youth at Risk for PsychosisRC1MH088546 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, TYRONE D · 2009 to 2010
$970k
NIH HHS MH088546NIMH NIH HHS R01 MH123575NIMH NIH HHS R37 MH085953NIMH NIH HHS RC1 MH088546
6 · The paper itself

Abstract

aimComorbid anxiety disorder is related to greater illness severity among individuals at clinical high risk (CHR) for psychosis, but its potential role in moderating response to Family Focused Therapy (FFT) for CHR is unexamined. We investigated whether comorbid anxiety disorder in CHR individuals is associated with less constructive communication during family problem-solving interactions, whether their communication skills differentially improve after FFT, and whether FFT is effective in reducing anxiety in this population.

methodsIndividuals recruited into the second phase of the 8-site North American Prodrome Longitudinal Study (NAPLS2) participated (N = 129). They were randomly assigned to 18-sessions of FFT-CHR or three-sessions of Enhanced Care (EC). Participants completed a diagnostic interview at pre-treatment, a family interaction task at pre-treatment and 6-months, and a self-report anxiety measure at pretreatment, 6 and 12-months.

resultsIndividuals at CHR with comorbid anxiety engaged in more negative and fewer positive behaviours during family problem-solving interactions at pre-treatment than did those without comorbid anxiety. There was a significant interaction between anxiety diagnosis and time on interactional behaviour scores, such that individuals at CHR with an anxiety diagnosis showed a greater decrease in negative behaviours and increase in positive behaviours from baseline to 6-months than those without anxiety disorder(s) regardless of treatment condition. However, individuals' self-reported anxiety symptoms decreased more in FFT-CHR than in EC from pre-treatment to 12-month follow-up, regardless of anxiety diagnoses.

conclusionsIndividuals at CHR with symptoms of anxiety benefit from family interventions in showing reductions in anxiety and improvements in family communication.

Indexed as

Psychotic DisordersAnxietyAnxiety DisordersCommunicationHumansLongitudinal StudiesProdromal Symptomsanxietyclinical high risk for psychosisenhanced carefamily focused treatmentfamily problem-solving interaction task

Identifiers

PMID35719024
PMCPMC10228682
OpenAlexW4283155387

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.