ArticleJournal of orthopaedic surgery and research2022
The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds.
Article in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- L1 vertebral body replacement using 3D-printed polylactic acid bioimplants:Journal of spine surgery (Hong Kong) · 2025Article
- Indirect 3D printing in tissue engineering: expanding materials used for improved scaffold functionality.Biomedical engineering online · 2025Review
- Synthesis and characterization of 3D gelatin/calcium hydroxide/dentin matrix proteins/propolis scaffolds for hard tissue engineering.BMC oral health · 2025Article
- Fabrication and evaluation of a host-guest polylactic acid/gelatin-hydroxyapatite-blueberry scaffold for bone regeneration.Journal of orthopaedic surgery and research · 2025Article
- Categories, applications, and potential of stem cells in bone regeneration: an overview.Frontiers in medicine · 2025Review
- On the osteogenic differentiation of dental pulp stem cells by a fabricated porous nano-hydroxyapatite substrate loaded with sodium fluoride.BMC oral health · 2024Article
- Mechanical Characterization of Polylactic Acid Composite Scaffolds Formed in Different Lattice Structures by Fused Deposition Modeling-Based 3D Printing.3D printing and additive manufacturing · 2024Article
- Emerging Biomedical and Clinical Applications of 3D-Printed Poly(Lactic Acid)-Based Devices and Delivery Systems.Bioengineering (Basel, Switzerland) · 2024Review
- Chitosan/Sodium Tripolyphosphate/Sodium Alginate/miRNA-34c-5p Antagomir Scaffolds Promote the Functionality of Rabbit Cranial Parietal Repair.International journal of nanomedicine · 2024Article
- Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis.International journal of nanomedicine · 2024Article
- A Synergic Strategy: Adipose-Derived Stem Cell Spheroids Seeded on 3D-Printed PLA/CHA Scaffolds Implanted in a Bone Critical-Size Defect Model.Journal of functional biomaterials · 2023Article
- Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region.ACS applied bio materials · 2023Review
- Addressable microfluidics technology for non-sacrificial analysis of biomaterial implantsBiomicrofluidics · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.