Evidence map›Paper›PMID 35726345›Full record

ArticleHepatology communications2022

Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells.

Yuki Imaoka, Koki Sato, Masahiro Ohira, Kouki Imaoka, Takuya Yano, Ryosuke Nakano, Yuka Tanaka, Hideki Ohdan

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. NK cells in HPV-related tumorigenesis: mechanisms and clinical applications.Frontiers in cellular and infection microbiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.ORCID 0000-0003-0882-5341
Koki SatoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.
Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.ORCID 0000-0002-5433-5303
Kouki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.
Takuya YanoDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Ryosuke NakanoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.
Yuka TanakaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3, Hiroshima, Japan.
Hiroshima University · JPHiroshima City Asa Citizens Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of acute portal hypertension (PHT), which is reported as poor prognostic factors in patients with hepatocellular carcinoma, are not well known on the liver immune system, including natural killer (NK) cells. The aim of this study, therefore, was to investigate how acute PHT influences the functions and characteristics of liver-resident NK (lr-NK) cells using an acute PHT mouse model. Acute PHT decreased the number of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL

Indexed as

Hypertension, PortalLiver NeoplasmsTNF-Related Apoptosis-Inducing LigandAnimalsAntineoplastic AgentsInterleukin-33Killer Cells, NaturalMicePortal VeinProto-Oncogene Proteins c-aktAntineoplastic AgentsInterleukin-33Proto-Oncogene Proteins c-aktTNF-Related Apoptosis-Inducing Ligandantitumor activitycytokinehepatic immune systemimmunologyportal hypertension

Identifiers

PMID35726345
PMCPMC9426399
OpenAlexW4283213786

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.