Evidence map›Paper›PMID 35727256›Full record

ArticleThe Journal of cell biology2022

Blood flow meets mitophagy.

Emir Bora Akmeriç, Holger Gerhardt

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emir Bora AkmeriçIntegrative Vascular Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Holger GerhardtIntegrative Vascular Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0002-3030-0384
Max Delbrück Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2's varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2's transcriptional dynamics.

Indexed as

Kruppel-Like Transcription FactorsMitochondriaMitophagyAnimalsHumansMiceKLF2 protein, humanKruppel-Like Transcription Factors

Identifiers

PMID35727256
PMCPMC9213090
OpenAlexW4283262652

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.