Evidence map›Paper›PMID 35728308›Full record

ArticleSleep medicine2022

Baroreflex sensitivity during rest and pressor challenges in obstructive sleep apnea patients with and without CPAP.

Amrita Pal, Fernando Martinez, Roopsha Chatterjee, Ravi S Aysola, Ronald M Harper, Vaughan G Macefield, Luke A Henderson, Paul M Macey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Amrita PalUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Fernando MartinezUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Roopsha ChatterjeeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Ravi S AysolaDivision of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
Ronald M HarperNeurobiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
Vaughan G MacefieldBaker Heart and Diabetes Institute, Melbourne, and Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, USA.
Luke A HendersonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, Australia.
Paul M MaceyUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: pmacey@ucla.edu.
University of California, Los Angeles · USThe University of Sydney · AU

Funding

GABA and glutamate changes underlying altered autonomic function in obstructive sleep apneaR01HL135562 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M, THOMAS, MICHAEL ALBERT · 2018 to 2021
$2.9M
Obstructive Sleep Apnea, Gender Biology, and Autonomic RegulationR01NR013693 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2013 to 2017
$2.0M
Gender Differences in Neural Deficits Associated with Obstructive Sleep ApneaR21NR011230 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2009 to 2010
$424k
Sex-specific brain injury and symptoms in sleep apneaR56NR017435 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2018 to 2018
$300k
NHLBI NIH HHS R01 HL135562NINR NIH HHS R01 NR013693NINR NIH HHS R21 NR011230NINR NIH HHS R56 NR017435
6 · The paper itself

Abstract

introductionObstructive sleep apnea (OSA) increases sympathetic vasoconstrictor drive and reduces baroreflex sensitivity (BRS), the degree to which blood pressure changes modify cardiac output. Whether nighttime continuous positive airway pressure (CPAP) corrects BRS in the awake state in OSA remains unclear. We assessed spontaneous BRS using non-invasive continuous BP and ECG recordings at rest and during handgrip and Valsalva challenges, maneuvers that increase vasoconstrictor drive with progressively higher BP, in untreated OSA (unOSA), CPAP-treated OSA (cpOSA) and healthy (CON) participants.

methodsIn a cross-sectional study of 104 participants, 34 unOSA (age mean±std, 50.6±14.1years; Respiratory Event Index [REI] 21.0±15.3 events/hour; 22male), 31 cpOSA (49.6±14.5years; REI 23.0±14.2 events/hour; 22male; self-report 4+hours/night,5+days/week,6months), and 39 CON (42.2±15.0years; 17male), we calculated BRS at rest and during handgrip and Valsalva. Additionally, we correlated BP variability (BPV) with BRS during these protocols.

resultsBRS in unOSA, cpOSA and CON was, respectively (mean±sdv in ms/mmHg), at rest: 14.8±11.8, 15.8±17.0, 16.1±11.3; during handgrip 13.3±7.6, 12.7±8.4, 16.4±8.7; and during Valsalva 12.7±8.0, 11.5±6.6, 15.1±8.9. BRS was lower in cpOSA than CON for handgrip (p=0.04) and Valsalva (p=0.03). BRS was negatively correlated with BPV in unOSA during Valsalva and handgrip for cpOSA, both R=-0.4 (p=0.02). BRS was negatively correlated with OSA severity (levels: none, mild, moderate, severe) at R=-0.2 (p=0.04,n=104).

conclusionsAs expected, BRS was lower and BPV higher in OSA during the pressor challenges, and disease severity negatively correlated with BRS. In this cross-sectional study, both CPAP-treated (self-reported) and untreated OSA showed reduced BRS, leaving open whether within-person CPAP improves BRS.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveAdultBaroreflexBlood PressureCross-Sectional StudiesHand StrengthHumansMiddle AgedVasoconstrictor AgentsVasoconstrictor AgentsAutonomicBlood pressure variabilityCardiovascular

Identifiers

PMID35728308
PMCPMC11600971
OpenAlexW4282013150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.