Evidence map›Paper›PMID 35728530›Full record

ArticleCurrent biology : CB2022

Autophagy: Identification of MTMR5 as a neuron-enriched suppressor.

Maria Chalokh Vogel, Sandra Maday

Open access · greenAbstract readComment
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria Chalokh VogelDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Sandra MadayDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: smaday@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Defining the roles and regulation of neuronal autophagyR01NS110716 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MADAY, SANDRA L. · 2020 to 2024
$2.0M
NINDS NIH HHS R01 NS110716
6 · The paper itself

Abstract

A puzzle of autophagy in neurons is that, unlike in other cells, it is not robustly induced by inhibition of mammalian target of rapamycin (mTOR). A new study now solves this conundrum and establishes that myotubularin-related phosphatase 5 limits the induction of neuronal autophagy by mTOR inhibitors.

Indexed as

AutophagyTOR Serine-Threonine KinasesNeuronsSirolimusSirolimusTOR Serine-Threonine Kinases

Identifiers

PMID35728530
PMCPMC9994184
OpenAlexW4283159168

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.