Evidence map›Paper›PMID 35729043›Full record

ArticleBrazilian journal of otorhinolaryngology

The effect of increase in blood glucose level on hearing loss.

Guven Akcay, Betul Danısman, Goksun Basaranlar, Pınar Guzel, Narin Derin, Alper Tunga Derin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Review
  4. Article
  5. The Repercussions of Hearing in Gestational Diabetes Patients.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Guven AkcayHitit University, Faculty of Medicine, Department of Biophysics, Çorum, Turkey.
Betul DanısmanAtatürk University, Faculty of Medicine, Department of Biophysics, Erzurum, Turkey.
Goksun Basaranlarİzmir Demokrasi University, Vocational School of Health Services, İzmir, Turkey.
Pınar GuzelKozan State Hospital, Department of Otolaryngology Head and Neck Surgery, Adana, Turkey.
Narin DerinAkdeniz University, Faculty of Medicine, Department of Biophysics, Antalya, Turkey. Electronic address: narinderin@akdeniz.edu.tr.
Alper Tunga DerinAkdeniz University, Faculty of Medicine, Department of Otolaryngology Head and Neck Surgery, Antalya, Turkey.
Akdeniz University · TRAtatürk University · TRHitit Üniversitesi · TRIzmir University · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious studies have shown that hearing function is also vulnerable to the effects of diabetes mellitus which can be shown by brainstem auditory evoked potential and distortion product otoacoustic emission recordings. This study aimed to investigate the changes of brainstem auditory evoked potential and distortion product otoacoustic emission in hyperglycemia and whether there is a relationship between reactive oxygen substances production and hearing deterioration in the rat model.

methods25 streptozotocin induced diabetic rats were divided into three groups: control, high blood glucose, and diabetes mellitus. Brainstem auditory evoked potential and distortion product otoacoustic emission were recorded, and thiobarbituric acid reactive substances levels were measured in the brainstem tissue.

resultsAt 8 kHz, the latencies of I, II, III, IV, and V brainstem auditory evoked potential waves in high blood glucose and diabetes mellitus groups were elongated, at 16 kHz, only these wave latencies of the diabetes mellitus group were prolonged compared with the control group. A significant decrease was also found in distortion product otoacoustic emission amplitudes at 4, 6, 8, and 10 kHz in the high blood glucose and diabetes mellitus groups compared to the control group. There was a significant increase in thiobarbituric acid reactive substances values due to the increase in blood glucose levels in the high blood glucose and diabetes mellitus groups compared to the control group.

conclusionThese results suggested that high blood glucose levels may cause hearing impairment not only in the diabetic state but also in the period of hyperglycemia before the onset of manifest diabetes mellitus and reactive oxygen substances may play an important role in the pathophysiology of diabetes mellitus. We suggest that regulating high glucose levels even before the onset of manifest diabetes mellitus may prevent hazardous effects on hearing function. LEVEL OF EVIDENCE: Level 3.

Indexed as

DeafnessDiabetes Mellitus, ExperimentalHearing LossHyperglycemiaAnimalsBlood GlucoseEvoked Potentials, Auditory, Brain StemOtoacoustic Emissions, SpontaneousOxygenRatsThiobarbituric Acid Reactive SubstancesBlood GlucoseOxygenThiobarbituric Acid Reactive SubstancesBrainstem auditory evoked potentialsDiabetes mellitusDistortion product otoacoustic emission

Identifiers

PMID35729043
PMCPMC9761000
OpenAlexW4282938552

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.