Evidence mapPaperPMID 35733752Full record

ArticleMaedica2022

Nephrotic Syndrome Complications - New and Old. Part 1.

Ruxandra Mihaela Busuioc, Gabriel Mircescu

Open access · hybridAbstract readEditorial
In one paragraph

Article in Maedica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Nephrotic Syndrome: Beyond Common Causes.Nephrology (Carlton, Vic.) · 2025
    Article
  3. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ruxandra Mihaela Busuioc"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Gabriel Mircescu"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nephrotic syndrome is a rare condition with an incidence of 2-7 cases/100.000 children per year and three new cases/100.000 adults per year. It occurs as a result of severe alteration of the glomerular filtration barrier of various causes, allowing proteins, mostly albumin, to be lost in the urine. Nephrotic syndrome complications are driven by the magnitude of either proteinuria or hypoalbuminemia, or both. Their frequency and severity vary with proteinuria and serum albumin level. Besides albumin, many other proteins are lost in urine. Therefore, nephrotic patients could have low levels of binding proteins for ions, vitamins, hormones, lipoproteins, coagulation factors. The liver tries to counterbalance these losses and will increase the unselective synthesis of all types of proteins. All of these changes will have different clinical consequences. The present paper aims to discuss the pathophysiological mechanism and new therapeutic recommendations for nephrotic syndrome edema and thromboembolic complications.

Identifiers

PMID35733752
PMCPMC9168581
OpenAlexW4283389547

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.