Evidence map›Paper›PMID 35734339›Full record

ArticleHealth science reports2022

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta-analysis.

Karam R Motawea, Omneya A Kandil, Joseph Varney, Merna Aboelenein, Nancy Ibrahim, Ahmed Shaheen, Lina T Khairy, Agyad Bakkour, Ali H H Muwaili, Dhuha H H Muwaili and 10 more

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In one paragraph

Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Karam R MotaweaFaculty of Medicine Alexandria University Alexandria Egypt.
Omneya A KandilFaculty of Medicine Alexandria University Alexandria Egypt.
Joseph VarneySchool of Medicine American University of the Caribbean Cupecoy Sint Maarten.
Merna AboeleneinFaculty of Medicine Alexandria University Alexandria Egypt.
Nancy IbrahimFaculty of Medicine Alexandria University Alexandria Egypt.
Ahmed ShaheenFaculty of Medicine Alexandria University Alexandria Egypt.
Lina T KhairyFaculty of Medicine The National Ribat University Al-Ribat Sudan.
Agyad BakkourFaculty of Medicine Albaath University Homs Syria.
Ali H H MuwailiFaculty of Medicine Ivano-Frankivsk National Medical University Ivano-Frankivsk Ukraine.
Dhuha H H MuwailiFaculty of Medicine Ivano-Frankivsk National Medical University Ivano-Frankivsk Ukraine.
Fatima A A AbdelmajidFaculty of Medicine University of Medical Sciences and Technology Khartoum Sudan.
Eman M S AhmadDepartments of Obstetrics and Gynecology Nile Valley University Atbra Sudan.
Mhd K AlbuniDepartment of Internal Medicine Hamad Medical Corporation Doha Qatar.
Elias BattikhDepartment of Internal Medicine Hamad Medical Corporation Doha Qatar.
Bisher SawafDepartment of Internal Medicine Hamad Medical Corporation Doha Qatar.
Sarya SwedFaculty of Medicine Aleppo University Aleppo Syria.ORCID 0000-0002-9983-2020
Safaa M A AhmedFaculty of Medicine Shendi University Shendi Sudan.
Dina M AwadFaculty of Medicine Alexandria University Alexandria Egypt.
Jaffer ShahMedical Research Center Kateb University Kabul Afghanistan.ORCID 0000-0002-8961-218X
Hani AiashCardiovascular perfusion Department Upstate Medical University Syracuse New York USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta-analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose tissue thickness. Methods: We searched the following databases: PUBMED, WOS, OVID, SCOPUS, and EMBASE. Inclusion criteria were any original articles that reported epicardial adipose tissue in FMF patients with no age restriction, excluding reviews, case reports, editorials, animal studies, and non-English studies. Thirty eligible studies were screened full text but only five studies were suitable. We used RevMan software (5.4) for the meta-analysis. Results: The total number of patients included in the meta-analysis in the FMF patients group is 256 (mean age = 24.3), and the total number in the control group is 188 (mean age = 24.98). The pooled analysis between FMF patients and controls was [mean difference = 0.82 (95% CI = 0.25-1.39), Conclusion: FMF patients are at increased risk of developing epicardial adipose tissue compared to controls. More multicenter studies with higher sample sizes are needed to support our results.

Indexed as

epicardial adipose tissuefamilial Mediterranean feverlipidsMeta analysis

Identifiers

PMID35734339
PMCPMC9193962

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.