Evidence map›Paper›PMID 35734588›Full record

ArticleFrontiers in oncology2022

Case Report: Sequential Development of Three Mature Lymphoid Neoplasms in a Single Patient: Clonal Relationship and Molecular Insights.

Chiara Salvetti, Candida Vitale, Valentina Griggio, Daniela Drandi, Rebecca Jones, Lisa Bonello, Riccardo Bomben, Alberto Bragoni, Davide Bagnara, Franco Fais and 4 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Chiara SalvettiDivision of Hematology, University of Torino, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
Candida VitaleDivision of Hematology, University of Torino, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
Valentina GriggioDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Daniela DrandiDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Rebecca JonesDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Lisa BonelloDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Riccardo BombenClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Alberto BragoniPathology Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Davide BagnaraDepartment of Experimental Medicine, University of Genova, Genova, Italy.
Franco FaisDepartment of Experimental Medicine, University of Genova, Genova, Italy.
Valter GatteiClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Federica CavalloDivision of Hematology, University of Torino, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
Alberto ZamòInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Marta CosciaDivision of Hematology, University of Torino, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITCentro di Riferimento Oncologico · ITOspedale Policlinico San Martino · ITUniversity of Genoa · ITUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two main variants of Richter syndrome (RS) are recognized, namely, the diffuse large B-cell lymphoma (DLBCL) and the Hodgkin's lymphoma (HL) variant. Clonal relationship, defined as an identity of the immunoglobulin heavy chain variable (IGHV) region sequence between chronic lymphocytic leukemia (CLL) and RS clones, characterizes patients with a poor prognosis. Due to method sensitivity, this categorization is performed without considering the possibility of small-size ancillary clones, sharing the same phenotype with the preexisting predominant CLL clone, but with different IGHV rearrangements. Here we describe and molecularly profile the peculiar case of a patient with a CLL-like monoclonal B-cell lymphocytosis (MBL), who sequentially developed a DLBCL, which occurred concomitantly to progression of MBL to CLL, and a subsequent HL. Based on standard IGHV clonality analysis, DLBCL was considered clonally unrelated to the concomitantly expanded CLL clone and treated as a

Indexed as

chronic lymphocytic leukemiaHodgkin lymphomaIGHV genesmonoclonal B-cell lymphocytosisRichter’s syndrome

Identifiers

PMID35734588
PMCPMC9207196
OpenAlexW4281749823

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.