Evidence map›Paper›PMID 35736877›Full record

ArticleTomography (Ann Arbor, Mich.)2022

Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-

Nikolaj Bøgh, Christoffer Laustsen, Esben S S Hansen, Hatice Tankisi, Lotte B Bertelsen, Jakob U Blicher

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Increasing Infusion Times of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  2. Review
  3. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  4. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikolaj BøghThe MR Research Center, Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.ORCID 0000-0002-0321-3269
Christoffer LaustsenThe MR Research Center, Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.ORCID 0000-0002-0317-2911
Esben S S HansenThe MR Research Center, Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.ORCID 0000-0001-5512-9870
Hatice TankisiDepartment of Clinical Neurophysiology, Aarhus University Hospital, 8200 Aarhus, Denmark.
Lotte B BertelsenThe MR Research Center, Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Jakob U BlicherCenter of Functionally Integrative Neuroscience, Aarhus University, 8200 Aarhus, Denmark.ORCID 0000-0003-3443-4790
Aarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cause of amyotrophic lateral sclerosis (ALS) is still unknown, and consequently, early diagnosis of the disease can be difficult and effective treatment is lacking. The pathology of ALS seems to involve specific disturbances in carbohydrate metabolism, which may be diagnostic and therapeutic targets. Magnetic resonance imaging (MRI) with hyperpolarized [1-

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesBicarbonatesHumansLactic AcidMagnetic Resonance ImagingPyruvic AcidBicarbonatesLactic AcidPyruvic Acidamyotrophic lateral sclerosishyperpolarizedmagnetic resonance imagingmetabolicneurodegenerationpyruvate

Identifiers

PMID35736877
PMCPMC9231312
OpenAlexW4282914286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.