ReviewCirculation research2022
Bioengineering Human Tissues and the Future of Vascular Replacement.
Review in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological tissue engineering for Fontan failure using decellularized extracellular matrix: a systematic review.Journal of translational medicine · 2026Pooled it
- Engineering Multiscale Vasculature: Biological Principles, Design Constraints, and Advanced Biofabrication Strategies for Functional Vascular Networks.Biomimetics (Basel, Switzerland) · 2026Review
- A Muscle-Mimetic Core-Sheath Composite Yarn Scaffold for In-Body Tissue Induction and Regeneration of Small-Diameter Vascular Grafts.Advanced healthcare materials · 2026Article
- Industrial Bioreactor Technologies for Modern Biomanufacturing: Recent Applications in Microbial, Mammalian, and Plant-Based Systems.Molecular biotechnology · 2026Review
- Chronic kidney disease and stromal cell-derived factor 1α peptide-functionalization impact on polycarbonate-bisurea based in situ tissue-engineered vascular graft dynamics.Scientific reports · 2026Article
- Charges, Reimbursement, and Healthcare Resource Utilization in Patients with Extremity Arterial Injury in the United States: Analysis of Linked Hospital Chargemaster and Claims Data.Healthcare (Basel, Switzerland) · 2026Article
- Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications.Journal of functional biomaterials · 2026Review
- Vascular Aging.Circulation · 2026Review
- Tissue compliance characterization for human umbilical arteries after decellularization.Journal of the mechanical behavior of biomedical materials · 2026Article
- Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts.Nature communications · 2026Article
- ProlongedACS omega · 2026Article
- Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.Device · 2026Article
- Decellularized porcine vascular grafts: structural integrity and translational potential for allogeneic implantation.Frontiers in bioengineering and biotechnology · 2026Article
- Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk.Nature communications · 2025Article
- Combining genome and tissue engineering for next-generation human biomimetics.Stem cells translational medicine · 2025Article
- Cardiac Tissue Bioprinting: Integrating Structure and Functions Through Biomimetic Design, Bioinks, and Stimulation.Gels (Basel, Switzerland) · 2025Review
- Novel Magnetically Charged Grafts for Vascular Repair: Process Optimization, Mechanical Characterization and In Vitro Validation.Polymers · 2025Article
- Self-healing and cell-free vascular grafts.Biomaterials · 2025Article
- Microenvironmental determinants of endothelial cell heterogeneity.Nature reviews. Molecular cell biology · 2025Review
- Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation.Journal of biological engineering · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cardiovascular defects, injuries, and degenerative diseases often require surgical intervention and the use of implantable replacement material and conduits. Traditional vascular grafts made of synthetic polymers, animal and cadaveric tissues, or autologous vasculature have been utilized for almost a century with well-characterized outcomes, leaving areas of unmet need for the patients in terms of durability and long-term patency, susceptibility to infection, immunogenicity associated with the risk of rejection, and inflammation and mechanical failure. Research to address these limitations is exploring avenues as diverse as gene therapy, cell therapy, cell reprogramming, and bioengineering of human tissue and replacement organs. Tissue-engineered vascular conduits, either with viable autologous cells or decellularized, are the forefront of technology in cardiovascular reconstruction and offer many benefits over traditional graft materials, particularly in the potential for the implanted material to be adopted and remodeled into host tissue and thus offer safer, more durable performance. This review discusses the key advances and future directions in the field of surgical vascular repair, replacement, and reconstruction, with a focus on the challenges and expected benefits of bioengineering human tissues and blood vessels.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.