Evidence map›Paper›PMID 35739995›Full record

ReviewAntioxidants (Basel, Switzerland)2022

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry.

Elena Obrador, Rosario Salvador-Palmer, Juan I Villaescusa, Eduardo Gallego, Blanca Pellicer, José M Estrela, Alegría Montoro

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena ObradorDepartment of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0002-5934-5543
Rosario Salvador-PalmerDepartment of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0002-0784-6776
Juan I VillaescusaService of Radiological Protection, Clinical Area of Medical Image, La Fe University Hospital, 46026 Valencia, Spain.
Eduardo GallegoEnergy Engineering Department, School of Industrial Engineering, Polytechnic University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-8338-4959
Blanca PellicerDepartment of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.
José M EstrelaDepartment of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain.
Alegría MontoroService of Radiological Protection, Clinical Area of Medical Image, La Fe University Hospital, 46026 Valencia, Spain.ORCID 0000-0003-1662-1592

Funding

Elysium Health OTR2017-17899INVESGeneralitat Valenciana INNVA1/2021/22Ministry of Economy, Industry and Competitiveness SAF2017-83458-R
6 · The paper itself

Abstract

Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed radiation exposure devices. Direct damage is caused when radiation interacts directly with cellular components. Indirect effects are mainly caused by the generation of reactive oxygen species due to radiolysis of water molecules. Acute and persistent oxidative stress associates to radiation-induced biological damages. Biological impacts of atomic radiation exposure can be deterministic (in a period range a posteriori of the event and because of destructive tissue/organ harm) or stochastic (irregular, for example cell mutation related pathologies and heritable infections). Potential countermeasures according to a specific scenario require considering basic issues, e.g., the type of radiation, people directly affected and first responders, range of doses received and whether the exposure or contamination has affected the total body or is partial. This review focuses on available medical countermeasures (radioprotectors, radiomitigators, radionuclide scavengers), biodosimetry (biological and biophysical techniques that can be quantitatively correlated with the magnitude of the radiation dose received), and strategies to implement the response to an accidental radiation exposure. In the case of large-scale atomic or radiological events, the most ideal choice for triage, dose assessment and victim classification, is the utilization of global biodosimetry networks, in combination with the automation of strategies based on modular platforms.

Indexed as

nuclear and radiological emergenciesradiation biodosimetryradiomitigatorsradionuclide scavengersradioprotectors

Identifiers

PMID35739995
PMCPMC9219873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.