Evidence map›Paper›PMID 35740239›Full record

ArticleBiomedicines2022

Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand.

Mihaela Turtoi, Maria Anghelache, Andrei A Patrascu, Mariana Deleanu, Geanina Voicu, Mihai Raduca, Florentina Safciuc, Ileana Manduteanu, Manuela Calin, Delia-Laura Popescu

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mihaela Turtoi"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.ORCID 0000-0001-6418-3406
Maria Anghelache"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.ORCID 0000-0002-2290-7338
Andrei A PatrascuDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Roşie, 020464 Bucharest, Romania.
Mariana Deleanu"Liquid and Gas Chromatography" Laboratory, Department of Lipidomics, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 050568 Bucharest, Romania.
Geanina Voicu"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.
Mihai RaducaDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Roşie, 020464 Bucharest, Romania.ORCID 0000-0002-3996-6094
Florentina Safciuc"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.
Ileana Manduteanu"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.ORCID 0000-0002-8079-4191
Manuela Calin"Medical and Pharmaceutical Bionanotechnologies" Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Hasdeu, 050568 Bucharest, Romania.ORCID 0000-0002-5245-160X
Delia-Laura PopescuDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Roşie, 020464 Bucharest, Romania.
Romanian Academy · ROUniversity of Bucharest · RO

Funding

Romanian Ministry of Education and Research, CNCS-UEFISCDI, PNCDI III PN-III-P1-1.1-PD-2019-0247Romanian Ministry of Education and Research, CNCS-UEFISCDI, PNCDI III PN-III-P4-ID-PCCF-2016-0050
6 · The paper itself

Abstract

A wide variety of metal-based compounds have been obtained and studied for their antitumor activity since the intensely used cytostatic drugs (e.g., cisplatin) failed to accomplish their expected pharmacological properties. Thus, we aimed to develop a new vanadium-based drug and assess its antitumor properties using the human hepatocarcinoma (HepG2) cell line. The compound was synthesized from vanadyl sulfate, DL-valine, and

Indexed as

3-methoxysalicylidenvaline ligandantitumor activityapoptosishepatocarcinomaoxidovanadium(V) complex

Identifiers

PMID35740239
PMCPMC9220379
OpenAlexW4281489494

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.