ReviewBiomedicines2022
Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance.
Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Maternal resistance exercise increases infant energy expenditure.American journal of physiology. Endocrinology and metabolism · 2025Trial
- Paternal obesity decreases infant MSC mitochondrial functional capacity.American journal of physiology. Endocrinology and metabolism · 2024Trial
- Association of the triglyceride-glucose index with all-cause and cause-specific mortality in patients with comorbid hypertension and diabetes: A population-based cohort study.American heart journal plus : cardiology research and practice · 2025Article
- Mitochondrial coupling efficiency and myofiber type related to blood pressure 22 h after high-intensity exercise in premenopausal women.European journal of applied physiology · 2025Article
- Iron Deficiency in Collegiate Athletes Obtaining Preparticipation Hemoglobinopathy Screening in the Upper Midwest.Pediatric blood & cancer · 2025Article
- Association of the triglyceride-glucose index with all-cause and cause-specific mortality: a population-based cohort study of 3.5 million adults in China.The Lancet regional health. Western Pacific · 2024Article
- Differences in substrate metabolism between African American and Caucasian infants: evidence from mesenchymal stem cells.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study.International journal of environmental research and public health · 2022Article
- The triglyceride-glucose index and mortality in chronic kidney and cardiovascular disease patients: A cohort study.Diabetes & vascular disease researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African Americans (AA) are disproportionately burdened by metabolic diseases. While largely unexplored between Caucasian (C) and AA, differences in mitochondrial bioenergetics may provide crucial insight to mechanisms for increased susceptibility to metabolic diseases. AA display lower total energy expenditure and resting metabolic rate compared to C, but paradoxically have a higher amount of skeletal muscle mass, suggestive of inherent energetic efficiency differences between these races. Such adaptations would increase the chances of overnutrition in AA; however, these disparities would not explain the racial difference in insulin resistance (IR) in healthy subjects. Hallmarks associated with insulin resistance (IR), such as reduced mitochondrial oxidative capacity and metabolic inflexibility are present even in healthy AA without a metabolic disease. These adaptations might be influential of mitochondrial "substrate preference" and could play a role in disproportionate IR rates among races. A higher glycolytic flux and provision of shuttles transferring electrons from cytosol to mitochondrial matrix could be a contributing factor in development of IR via heightened reactive oxygen species (ROS) production. This review highlights the above concepts and provides suggestions for future studies that could help delineate molecular premises behind potential impairments in insulin signaling and metabolic disease susceptibility in AA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.