Evidence map›Paper›PMID 35740956›Full record

ReviewBiomolecules2022

Spatiotemporal Coupling of DNA Supercoiling and Genomic Sequence Organization-A Timing Chain for the Bacterial Growth Cycle?

Georgi Muskhelishvili, Patrick Sobetzko, Andrew Travers

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Microbial Primer: Bacterial DNA supercoiling.Microbiology (Reading, England) · 2026
    Review
  2. Transcription activation inEcoSal Plus · 2024
    Review
  3. Recollections of a Helmstetter Disciple.Life (Basel, Switzerland) · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Georgi MuskhelishviliSchool of Natural Sciences, Biology Program, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Patrick SobetzkoSynmikro, Loewe Center for Synthetic Microbiology, Philipps-Universität Marburg, 35043 Marburg, Germany.ORCID 0000-0001-5758-1529
Andrew TraversMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Agricultural University of Georgia · GEMRC Laboratory of Molecular Biology · GBPhilipps University of Marburg · DE

Funding

Medical Research Council MC_U105178783
6 · The paper itself

Abstract

In this article we describe the bacterial growth cycle as a closed, self-reproducing, or autopoietic circuit, reestablishing the physiological state of stationary cells initially inoculated in the growth medium. In batch culture, this process of self-reproduction is associated with the gradual decline in available metabolic energy and corresponding change in the physiological state of the population as a function of "travelled distance" along the autopoietic path. We argue that this directional alteration of cell physiology is both reflected in and supported by sequential gene expression along the chromosomal OriC-Ter axis. We propose that during the

Indexed as

Chromosomes, BacterialDNA, SuperhelicalBacterial ProteinsDNADNA, BacterialEscherichia coliGene Expression Regulation, BacterialGenomicsBacterial ProteinsDNADNA, BacterialDNA, Superhelicalbacterial growth cycleDNA sequence organizationDNA supercoilinggrowth phase-dependent gene expressionnucleoid-associated proteins

Identifiers

PMID35740956
PMCPMC9221221
OpenAlexW4282966506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.