Evidence map›Paper›PMID 35741675›Full record

ReviewBrain sciences2022

Vitamin D Status and Parkinson's Disease.

Michela Barichella, Federica Garrì, Serena Caronni, Carlotta Bolliri, Luciano Zocchi, Maria Carmela Macchione, Valentina Ferri, Daniela Calandrella, Gianni Pezzoli

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026
    Review
  6. Article
  7. Review
  8. Parkinson's disease and vitamins: a focus on vitamin B12.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. The Role of Diet in Parkinson's Disease.Journal of Parkinson's disease · 2024
    Review
  14. Review
  15. Does vitamin D protect or treat Parkinson's disease? A narrative review.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  16. Review
  17. Potential role of vitamin D levels in amyotrophic lateral sclerosis cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Michela BarichellaParkinson Institute, ASST Gaetano Pini-CTO, 20126 Milan, Italy.
Federica GarrìFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Serena CaronniFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Carlotta BolliriFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Luciano ZocchiDipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Sezione di Fisiologia, 20133 Milan, Italy.
Maria Carmela MacchioneFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Valentina FerriFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Daniela CalandrellaFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Gianni PezzoliFondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy.
Grigioni Foundation for Parkinson's disease · ITIstituto Ortopedico Gaetano Pini · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.

Indexed as

hypovitaminosis DParkinson’s diseasevitamin Dvitamin D deficiencyvitamin D insufficiencyvitamin D receptor (VDR) polymorphisms

Identifiers

PMID35741675
PMCPMC9221008
OpenAlexW4283076774

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.