Evidence map›Paper›PMID 35742860›Full record

ArticleInternational journal of molecular sciences2022

Combining Recombinase-Mediated Cassette Exchange Strategy with Quantitative Proteomic and Phosphoproteomic Analyses to Inspect Intracellular Functions of the Tumor Suppressor Galectin-4 in Colorectal Cancer Cells.

Malwina Michalak, Viola Golde, Dominik Helm, Herbert Kaltner, Johannes Gebert, Jürgen Kopitz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Oncology letters · 2025
    Article
  4. Article
  5. Proteomics and Its Applications in Cancers.International journal of molecular sciences · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Malwina MichalakDepartment of Applied Tumor Biology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
Viola GoldeDepartment of Applied Tumor Biology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.ORCID 0000-0002-0880-4121
Dominik HelmProteomics Core Facility, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Herbert KaltnerVeterinary Faculty, Institute of Physiological Chemistry, Ludwig-Maximilians-University, 80539 München, Germany.ORCID 0000-0003-4680-8411
Johannes GebertDepartment of Applied Tumor Biology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.ORCID 0000-0002-0606-7818
Jürgen KopitzDepartment of Applied Tumor Biology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
German Cancer Research Center · DEHeidelberg University · DELudwig-Maximilians-Universität München · DE

Funding

Deutsche Forschungsgemeinschaft MI 2682/2-1
6 · The paper itself

Abstract

Galectin-4 (Gal4) has been suggested to function as a tumor suppressor in colorectal cancer (CRC). In order to systematically explore its function in CRC, we established a CRC cell line where Gal4 expression can be regulated via the doxycycline (dox)-inducible expression of a single copy wildtype

Indexed as

Colorectal NeoplasmsProteomicsCell Line, TumorDNA-Binding ProteinsForkhead Transcription FactorsGalectin 4HumansIntracellular SpaceRecombinasesTranscription FactorsDNA-Binding ProteinsForkhead Transcription FactorsFOXK1 protein, humanGalectin 4RecombinasesTranscription FactorsZBTB7A protein, humancolorectal cancerGalectin 4phosphoproteomicsproteomicsTet-On system

Identifiers

PMID35742860
PMCPMC9223697
OpenAlexW4281675124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.