Evidence map›Paper›PMID 35743249›Full record

ReviewInternational journal of molecular sciences2022

Breast Cancer Metastasis: Mechanisms and Therapeutic Implications.

Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 5 pooled it
35.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 5 syntheses or guidelines pooled it, 362 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  8. Review
  9. Article
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  11. Article
  12. Investigating the predictive role of inflammatory indices in cancer metastasis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  13. Article
  14. [Erianin inhibits proliferation and migration of breast cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
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  16. Article
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  18. Review
  19. Article
  20. Review

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Misung ParkDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Dohee KimDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Sunghyub KoDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Ayoung KimDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Kyumin MoDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Hyunho YoonDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea.
Catholic University of Korea · KR

Funding

Korea Ministry of Education M2022B002600003
6 · The paper itself

Abstract

Breast cancer is the most common malignancy in women worldwide. Metastasis is the leading cause of high mortality in most cancers. Although predicting the early stage of breast cancer before metastasis can increase the survival rate, breast cancer is often discovered or diagnosed after metastasis has occurred. In general, breast cancer has a poor prognosis because it starts as a local disease and can spread to lymph nodes or distant organs, contributing to a significant impediment in breast cancer treatment. Metastatic breast cancer cells acquire aggressive characteristics from the tumor microenvironment (TME) through several mechanisms including epithelial-mesenchymal transition (EMT) and epigenetic regulation. Therefore, understanding the nature and mechanism of breast cancer metastasis can facilitate the development of targeted therapeutics focused on metastasis. This review discusses the mechanisms leading to metastasis and the current therapies to improve the early diagnosis and prognosis in patients with metastatic breast cancer.

Indexed as

Breast NeoplasmsNeoplasms, Second PrimaryEpigenesis, GeneticEpithelial-Mesenchymal TransitionFemaleHumansLymph NodesNeoplasm MetastasisTumor Microenvironmentbreast cancerEMTmetastasistumor microenvironment

Identifiers

PMID35743249
PMCPMC9224686
OpenAlexW4283122919

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.