Evidence map›Paper›PMID 35743315›Full record

ArticleInternational journal of molecular sciences2022

Trehalose Treatment in Zebrafish Model of Lafora Disease.

Stefania Della Vecchia, Asahi Ogi, Rosario Licitra, Francesca Abramo, Gabriele Nardi, Serena Mero, Silvia Landi, Roberta Battini, Federico Sicca, Gian Michele Ratto and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Converging Role for REEP1/SPG31 in Oxidative Stress.International journal of molecular sciences · 2023
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Stefania Della VecchiaDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.
Asahi OgiDepartment Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.ORCID 0000-0002-2089-7412
Rosario LicitraDepartment Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.ORCID 0000-0003-4879-6610
Francesca AbramoDepartment of Veterinary Science, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0003-4414-4359
Gabriele NardiNational Enterprise for Nanoscience and Nanotechnology (NEST), Consiglio Nazionale delle Ricerche (CNR)-Istituto Nanoscienze and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.ORCID 0000-0003-0475-2771
Serena MeroDepartment Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.
Silvia LandiNational Enterprise for Nanoscience and Nanotechnology (NEST), Consiglio Nazionale delle Ricerche (CNR)-Istituto Nanoscienze and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.ORCID 0000-0001-7999-3452
Roberta BattiniDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.
Federico SiccaChild Neuropsychiatric Unit, USL Centro Toscana, 59100 Prato, Italy.
Gian Michele RattoNational Enterprise for Nanoscience and Nanotechnology (NEST), Consiglio Nazionale delle Ricerche (CNR)-Istituto Nanoscienze and Scuola Normale Superiore Pisa, 56127 Pisa, Italy.ORCID 0000-0001-9632-7769
Filippo Maria SantorelliDepartment Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.ORCID 0000-0002-1359-9062
Maria MarcheseDepartment Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy.ORCID 0000-0002-0194-0702
Fondazione Stella Maris · ITUniversity of Pisa · ITIstituto Nanoscienze · ITAzienda Usl Toscana Centro · ITIstituto di Scienza e Tecnologie dell'Informazione "Alessandro Faedo" · IT

Funding

Fondazione Cassa di Risparmio di Lucca CARILUCCAMinistero della Salute Ricerca Corrente5x1000Ministero della Salute Staring Grant SG-2018-12367839Regione Toscana Bando Salute 2018-DEM-AGING
6 · The paper itself

Abstract

Mutations in the

Indexed as

Lafora DiseaseAnimalsMutationProtein Tyrosine Phosphatases, Non-ReceptorSeizuresTrehaloseUbiquitin-Protein LigasesZebrafishProtein Tyrosine Phosphatases, Non-ReceptorTrehaloseUbiquitin-Protein LigasesautophagyLafora diseaseneuroinflammationprogressive myoclonic epilepsiestrehalose

Identifiers

PMID35743315
PMCPMC9224929
OpenAlexW4283204013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.