Evidence map›Paper›PMID 35743346›Full record

ArticleJournal of clinical medicine2022

Olfactory Training in Post-COVID-19 Persistent Olfactory Disorders: Value Normalization for Threshold but Not Identification.

Clair Vandersteen, Magali Payne, Louise-Émilie Dumas, Élisa Cancian, Alexandra Plonka, Grégoire D'Andréa, David Chirio, Élisa Demonchy, Karine Risso, Florence Askenazy-Gittard and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Regenerating smell in neurodegenerative disease -translating theory into therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  4. Article
  5. Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review.International archives of otorhinolaryngology · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Olfactory Evaluation in Clinical Medical Practice.Journal of clinical medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Clair VandersteenInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.ORCID 0000-0001-5597-2040
Magali PayneLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.
Louise-Émilie DumasLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.
Élisa CancianInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.
Alexandra PlonkaLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.ORCID 0000-0002-1016-2834
Grégoire D'AndréaInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.ORCID 0000-0003-3838-513X
David ChirioDépartement de Médecine Infectiologique, Hôpital de l'archet, Centre Hospitalier Universitaire, Université Côte d'Azur, 151 Route de Saint-Antoine, 06200 Nice, France.
Élisa DemonchyDépartement de Médecine Infectiologique, Hôpital de l'archet, Centre Hospitalier Universitaire, Université Côte d'Azur, 151 Route de Saint-Antoine, 06200 Nice, France.
Karine RissoDépartement de Médecine Infectiologique, Hôpital de l'archet, Centre Hospitalier Universitaire, Université Côte d'Azur, 151 Route de Saint-Antoine, 06200 Nice, France.
Florence Askenazy-GittardLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.
Charles SavoldelliInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.
Nicolas GuevaraInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.ORCID 0000-0002-4286-6465
Philippe RobertLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.ORCID 0000-0002-0963-1728
Laurent CastilloInstitut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire, Université Côte d'Azur, 31 Avenue de Valombrose, 06100 Nice, France.
Valeria ManeraLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.
Auriane GrosLaboratoire CoBTeK, Université Côte d'Azur, 06100 Nice, France.
Université Côte d'Azur · FRInstitut national de recherche en sciences et technologies du numérique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Persistent post-viral olfactory disorders (PPVOD) are estimated at 30% of patients one year after COVID-19 infection. No treatment is, to date, significantly effective on PPVOD with the exception of olfactory training (OT). The main objective of this work was to evaluate OT efficiency on post-COVID-19 PPVOD. (2) Methods: Consecutive patients consulting to the ENT department with post-COVID-19 PPVOD were included after completing clinical examination, the complete Sniffin’ Stick Test (TDI), the short version of the Questionnaire of olfactory disorders and the SF-36. Patients were trained to practice a self-olfactory training with a dedicated olfactory training kit twice a day for 6 months before returning to undergo the same assessments. (3) Results: Forty-three patients were included and performed 3.5 months of OT in average. We observed a significant TDI score improvement, increasing from 24.7 (±8.9) before the OT to 30.9 (±9.8) (p < 0.001). Based on normative data, a significant increase in the number of normosmic participants was observed only for the threshold values (p < 0.001). Specific and general olfaction-related quality of life improved after the OT. (4) Conclusions: Olfactory function appeared to improve only in peripheral aspects of post-COVID-19 PPVOD after OT. Future controlled studies must be performed to confirm the OT role and justify new therapeutic strategies that may focus on the central aspects of post-COVID-19 PPVOD.

Indexed as

COVID-19olfaction disordersolfactory trainingparosmia

Identifiers

PMID35743346
PMCPMC9224948
OpenAlexW4281613170

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.