Evidence map›Paper›PMID 35744995›Full record

ArticleMolecules (Basel, Switzerland)2022

Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines.

Ekaterina V Neborak, Altynay B Kaldybayeva, Lylia Bey, Aigul Y Malmakova, Anna S Tveritinova, Abdullah Hilal, Valentina K Yu, Maria V Ploskonos, Marina V Komarova, Enzo Agostinelli and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Ekaterina V NeborakDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), 8 Miklukho-Maklaya St., Moscow 117198, Russia.
Altynay B KaldybayevaLaboratory of Chemistry of Synthetic and Natural Medicinal Substances, A.B. Bekturov Institute of Chemical Sciences, 59 Tole bi St., Almaty 050000, Kazakhstan.ORCID 0000-0003-2805-3633
Lylia BeyDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), 8 Miklukho-Maklaya St., Moscow 117198, Russia.
Aigul Y MalmakovaLaboratory of Chemistry of Synthetic and Natural Medicinal Substances, A.B. Bekturov Institute of Chemical Sciences, 59 Tole bi St., Almaty 050000, Kazakhstan.
Anna S TveritinovaDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), 8 Miklukho-Maklaya St., Moscow 117198, Russia.
Abdullah HilalLaboratory of Medical Biotechnology, Institute of Biomedical Chemistry, 10/8 Pogodinskaya St., Moscow 119121, Russia.
Valentina K YuLaboratory of Chemistry of Synthetic and Natural Medicinal Substances, A.B. Bekturov Institute of Chemical Sciences, 59 Tole bi St., Almaty 050000, Kazakhstan.
Maria V PloskonosDepartment of Chemistry, Astrakhan State Medical University, Astrakhan 414000, Russia.
Marina V KomarovaDepartment of Laser and Biotechnical Systems, Samara University, 34 Moskovskoye Shosse, Samara 443086, Russia.
Enzo AgostinelliDepartment of Sensory Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, University Hospital Policlinico Umberto I, I-00161 Rome, Italy.ORCID 0000-0002-2508-8868
Dmitry D ZhdanovDepartment of Biochemistry, Peoples' Friendship University of Russia (RUDN University), 8 Miklukho-Maklaya St., Moscow 117198, Russia.ORCID 0000-0003-4753-7588
Peoples' Friendship University of Russia · RUAl-Farabi Kazakh National University · KZAstrakhan State Medical University · RUInstitute of Biomedical Chemistry · RUPoliclinico Umberto I · ITSamara National Research University · RU

Funding

The Ministry of Education and Science of the Russian Federation No. 075-15-2021-933
6 · The paper itself

Abstract

Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells. Chemical compounds able to restore the level of PA catabolism in tumors could become potential antineoplastic agents. The search for activators of PA catabolism among bicyclononan-9-ones is a promising strategy for drug development. The aim of the study was to evaluate the biological activity of new 3,7-diazabicyclo[3.3.1]nonan-9-one derivatives that have antiproliferative properties by accelerating PA catabolism. Eight bispidine derivatives were synthetized and demonstrated the ability to activate PA catabolism in regenerating rat liver homogenates. However, only three of them demonstrated a potent ability to decrease the viability of cancer cells in the MTT assay. Compounds

Indexed as

Antineoplastic AgentsNeoplasmsAnimalsApoptosisBridged Bicyclo Compounds, HeterocyclicCell Line, TumorCell ProliferationPolyaminesRatsStructure-Activity RelationshipAntineoplastic AgentsbispidineBridged Bicyclo Compounds, HeterocyclicPolyaminesantiproliferative activityapoptosis inductionbispidinescancer cell linescytotoxicityHepG2polyamine analogspolyamine catabolismpolyaminesscreeningWI38

Identifiers

PMID35744995
PMCPMC9229528
OpenAlexW4283028893

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.